Phenotypes associated with this allele

• Allele Symbol: Kdr^tm1.1Msh
• Allele Name: targeted mutation 1.1, Masabumi Shibuya
• Allele ID: MGI:3530468
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdr^tm1.1Msh/Kdr^tm1.1Msh	involves: 129P2/OlaHsd * C57BL/6J	MGI:3531323
ht2	Kdr^tm1Jrt/Kdr^tm1.1Msh	involves: 129P2/OlaHsd * B6.129-Kdr^tm1Jrt/J * C57BL/6J	MGI:3531324

Genotype
MGI:3531323

hm1

• Allelic Composition: Kdr^tm1.1Msh/Kdr^tm1.1Msh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:96124 )

• embryos die between E8.5 and E9.5

cardiovascular system

absent organized vascular network ( J:96124 )

• at E9.5 no blood vessels are seen

absent vitelline blood vessels ( J:96124 )

• at E9.5

embryo

absent vitelline blood vessels ( J:96124 )

• at E9.5

hematopoietic system

impaired hematopoiesis ( J:96124 )

• the number of hematopoietic progenitors and the number of erythroid, granulocyte/macrophage and mixed colonies formed are severely reduced

Genotype
MGI:3531324

ht2

• Allelic Composition: Kdr^tm1Jrt/Kdr^tm1.1Msh
• Genetic Background: involves: 129P2/OlaHsd * B6.129-Kdr^tm1Jrt/J * C57BL/6J

cardiovascular system

abnormal dorsal aorta morphology ( J:96124 )

• at E8.5, dorsal aorta is absent

absent organized vascular network ( J:96124 )

• at E8.5 vessels in the head as well as the dorsal aorta and vitelline artery are absent

embryo

absent visceral yolk sac blood islands ( J:96124 )

• at E7.5

abnormal extraembryonic mesoderm development ( J:96124 )

• at E7.5 the extraembryonic mesoderm consists of only a single cell layer