Phenotypes associated with this allele

• Allele Symbol: Bag3^{Gt(OST16086)Lex}
• Allele Name: gene trap OST16086, Lexicon Genetics
• Allele ID: MGI:3530294
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bag3^Gt(OST16086)Lex/Bag3^Gt(OST16086)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3716995

Genotype
MGI:3716995

hm1

• Allelic Composition: Bag3^{Gt(OST16086)Lex}/Bag3^{Gt(OST16086)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:112361 )

• all mice are dead by day 25

growth/size/body

disproportionate dwarf ( J:112361 )

• after 1 week of birth mice appear dwarfed

postnatal growth retardation ( J:112361 )

• mice fail to gain weight after day 12

muscle

myocardial fiber degeneration ( J:112361 )

• at day 20

increased cardiomyocyte apoptosis ( J:112361 )

• at day 20, massive amounts of apoptosis is observed in myocardial fibers

abnormal Z line morphology ( J:112361 )

• at day 4, the Z-disk morphology is abnormal

abnormal skeletal muscle morphology ( J:112361 )

• at day 20, massive amounts of apoptosis is observed in skeletal muscles

skeletal muscle fiber degeneration ( J:112361 )

• at day 20, skeletal myofiber degeneration occurs without inflammation

• striking degeneration is seen in the diaphragm, soleus, and vastus intermedius muscles

• little degeneration is observed in the tibialis anterior, extensor digitorum longus, rectus femoris, vastus lateralis, and vastus medialis

cardiovascular system

myocardial fiber degeneration ( J:112361 )

• at day 20

increased cardiomyocyte apoptosis ( J:112361 )

• at day 20, massive amounts of apoptosis is observed in myocardial fibers

respiratory system

pulmonary edema ( J:112361 )

homeostasis/metabolism

pulmonary edema ( J:112361 )

cellular

increased cardiomyocyte apoptosis ( J:112361 )

• at day 20, massive amounts of apoptosis is observed in myocardial fibers