Phenotypes associated with this allele

• Allele Symbol: Svep1⁺
• Allele Name: wild type
• Allele ID: MGI:3529853
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Svep1^tm1b(EUCOMM)Hmgu/Svep1^+	C57BL/6N-Svep1^tm1b(EUCOMM)Hmgu/J	MGI:5757779
cx2	Apoe^tm1Unc/Apoe^tm1Unc Svep1^tm1a(EUCOMM)Hmgu/Svep1^+	involves: 129P2/OlaHsd * C57BL/6N	MGI:7516350

Genotype
MGI:5757779

ht1

• Allelic Composition: Svep1^{tm1b(EUCOMM)Hmgu}/Svep1⁺
• Genetic Background: C57BL/6N-Svep1^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0747_6_B06

Data Sources

IMPC Data for Svep1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

prolonged QRS complex duration ( J:211773 )

♂

IMPC - JAX

hematopoietic system

increased erythrocyte cell number ( J:211773 )

♂

IMPC - JAX

increased hematocrit ( J:211773 )

♂

IMPC - JAX

increased hemoglobin content ( J:211773 )

♀

IMPC - JAX

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

♂

IMPC - JAX

decreased circulating phosphate level ( J:211773 )

♀

IMPC - JAX

decreased circulating sodium level ( J:211773 )

♀

IMPC - JAX

Genotype
MGI:7516350

cx2

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Svep1^{tm1a(EUCOMM)Hmgu}/Svep1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

cardiovascular system

abnormal artery morphology ( J:304349 )

• reduced atherosclerotic plaque burden in whole aorta and aortic arch and root after 8 weeks of HFD feeding

• reduced macrophage invasion of aortic root neointima after 8 weeks of HFD feeding

growth/size/body

growth/size/body region phenotype ( J:304349 )

N • normal body weight after 8 weeks of HFD feeding

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:304349 )

N • normal plasma total cholesterol, triglycerides and glucose levels after 8 weeks of HFD feeding