Phenotypes associated with this allele

• Allele Symbol: Degs1^{Gt(OST368559)Lex}
• Allele Name: gene trap OST368559, Lexicon Genetics
• Allele ID: MGI:3529540
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Degs1^Gt(OST368559)Lex/Degs1^Gt(OST368559)Lex	involves: 129S5/SvEvBrd	MGI:5527441
ht2	Degs1^Gt(OST368559)Lex/Degs1^+	involves: 129S5/SvEvBrd	MGI:5527442

Genotype
MGI:5527441

hm1

• Allelic Composition: Degs1^{Gt(OST368559)Lex}/Degs1^{Gt(OST368559)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:203554 )

• mice die between 8 and 10 weeks

preweaning lethality, incomplete penetrance ( J:203554 )

• fewer than expected mice are observed among the offspring of heterozygous mice

homeostasis/metabolism

abnormal homeostasis ( J:203554 )

increased circulating bilirubin level ( J:203554 )

increased circulating alanine transaminase level ( J:203554 )

increased circulating alkaline phosphatase level ( J:203554 )

abnormal ceramide level ( J:203554 )

• reduced ceramide with more dihydroceramide in pups

• lack of ceramide in the heart, liver, pancreas, white adipose tissue and soleus muscle from 7 weeks

growth/size/body

decreased lean body mass ( J:203554 )

decreased body size ( J:203554 )

decreased body weight ( J:203554 )

decreased body length ( J:203554 )

postnatal growth retardation ( J:203554 )

skeleton

decreased bone mineral content ( J:203554 )

decreased bone mineral density ( J:203554 )

integument

sparse hair ( J:203554 )

scaly skin ( J:203554 )

behavior/neurological

tremors ( J:203554 )

hematopoietic system

abnormal hematopoietic system morphology/development ( J:203554 )

• numerous hematological abnormalities

liver/biliary system

decreased liver function ( J:203554 )

Genotype
MGI:5527442

ht2

• Allelic Composition: Degs1^{Gt(OST368559)Lex}/Degs1⁺
• Genetic Background: involves: 129S5/SvEvBrd

homeostasis/metabolism

increased insulin sensitivity ( J:203554 )

• in untreated and dexamethasone-treated mice

abnormal ceramide level ( J:203554 )

• reduced ratio of active ceramide to inactive dihydroceramide compared with wild-type mice

muscle

increased muscle cell glucose uptake ( J:203554 )

• increased in insulin-treated muscles in the presence of palmitate

• however, basal uptake and insulin-stimulated uptake in the presence of linoleate are normal

cellular

increased muscle cell glucose uptake ( J:203554 )

• increased in insulin-treated muscles in the presence of palmitate

• however, basal uptake and insulin-stimulated uptake in the presence of linoleate are normal