All Phenotypes Ap4b1<tm1Lex> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ap4b1^tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529172

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ap4b1^tm1Lex/Ap4b1^tm1Lex	B6.129S-Ap4b1^tm1Lex	MGI:3814230

Allelic Composition	Ap4b1^tm1Lex/Ap4b1^tm1Lex
Genetic Background	B6.129S-Ap4b1^tm1Lex

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap4b1^tm1Lex mutation (1 available); any Ap4b1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:135974 )

• mice perform significantly poorer on a rotarod compared to wild-type mice

nervous system

nervous system phenotype ( J:135974 )

N	• mice exhibit normal brain foliation and normal laminated cortical structure

abnormal Purkinje cell morphology ( J:135974 )

• sub-cellular localization of AMPA receptors is disrupted

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24