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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk14tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529043
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mapk14tm1Lex/Mapk14tm1Lex
Myl7tm1(cre)Krc/Myl7+ 		involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:3580021
cn2
 		Mapk14tm1Lex/Mapk14tm1Lex
Tg(Myog-cre)1Eno/0 		involves: 129S5/SvEvBrd MGI:4415790


Genotype
MGI:3580021
cn1
Allelic
Composition		 Mapk14tm1Lex/Mapk14tm1Lex
Myl7tm1(cre)Krc/Myl7+
Genetic
Background		 involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14tm1Lex mutation (1 available); any Mapk14 mutation (41 available)
Myl7tm1(cre)Krc mutation (0 available); any Myl7 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal fetal cardiomyocyte proliferation ( J:98514 )
• homozygous mice that are heterozygous for Myl7 tm1(cre)Krc, in which cre mediated recombination is induced in cardiomyocytes, display increased mitosis in 4 day old and adult mice cardiomyocytes

muscle
abnormal fetal cardiomyocyte proliferation ( J:98514 )
• homozygous mice that are heterozygous for Myl7 tm1(cre)Krc, in which cre mediated recombination is induced in cardiomyocytes, display increased mitosis in 4 day old and adult mice cardiomyocytes

cellular
abnormal fetal cardiomyocyte proliferation ( J:98514 )
• homozygous mice that are heterozygous for Myl7 tm1(cre)Krc, in which cre mediated recombination is induced in cardiomyocytes, display increased mitosis in 4 day old and adult mice cardiomyocytes




Genotype
MGI:4415790
cn2
Allelic
Composition		 Mapk14tm1Lex/Mapk14tm1Lex
Tg(Myog-cre)1Eno/0
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14tm1Lex mutation (1 available); any Mapk14 mutation (41 available)
Tg(Myog-cre)1Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:155408 )
N
• mice exhibit normal angiogenesis in response to endurance exercise

cellular
cellular phenotype ( J:155408 )
N
• mice exhibit normal mitochondrial biogenesis in response to endurance exercise

muscle
muscle phenotype ( J:155408 )
N
• mice exhibit normal fiber-type transformation in response to endurance exercise




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory