Phenotypes associated with this allele

• Allele Symbol: Kl^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528832
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kl^tm1Lex/Kl^tm1Lex	B6.129S-Kl^tm1Lex	MGI:5052066
hm2	Kl^tm1Lex/Kl^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3609938
cx3	Kl^tm1Lex/Kl^tm1Lex Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan	involves: 129S/SvEvBrd * C57BL/6	MGI:5052065

Genotype
MGI:5052066

hm1

• Allelic Composition: Kl^tm1Lex/Kl^tm1Lex
• Genetic Background: B6.129S-Kl^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating calcium level ( J:173962 )

increased circulating phosphate level ( J:173962 )

growth/size/body

decreased body size ( J:173962 )

• at 6 weeks

Genotype
MGI:3609938

hm2

• Allelic Composition: Kl^tm1Lex/Kl^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

mortality/aging

premature death ( J:103485 )

• homozygotes are sickly and most die by 9 to 10 weeks of age

growth/size/body

decreased body weight ( J:103485 )

• body weight, mean total tissue mass, and lean body mass are reduced

decreased body length ( J:103485 )

skeleton

abnormal femur morphology ( J:103485 )

• mean femoral midshaft cortical thickness is reduced

abnormal trabecular bone morphology ( J:103485 )

• mean trabecular bone volume and thickness are increased

limbs/digits/tail

abnormal femur morphology ( J:103485 )

• mean femoral midshaft cortical thickness is reduced

Genotype
MGI:5052065

cx3

• Allelic Composition: Kl^tm1Lex/Kl^tm1Lex; Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

mortality/aging

premature death ( J:173962 )

• average life span is 14 to 16 weeks

homeostasis/metabolism

increased circulating phosphate level ( J:173962 )

digestive/alimentary system

abnormal digestive system morphology ( J:173962 )

• mice exhibit intestinal atrophy unlike wild-type mice

respiratory system

emphysema ( J:173962 )

renal/urinary system

nephrocalcinosis ( J:173962 )

cardiovascular system

calcified artery ( J:173962 )

growth/size/body

decreased body size ( J:173962 )

• at 3 and 6 weeks