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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itktm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528811
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itktm1Lex/Itktm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609963


Genotype
MGI:3609963
hm1
Allelic
Composition		 Itktm1Lex/Itktm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itktm1Lex mutation (2 available); any Itk mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:103485 )
• notable increase in mean percentage of B cells
decreased CD4-positive, alpha-beta T cell number ( J:103485 )
• notable decrease in percentage of CD4+ cells
decreased CD8-positive, alpha-beta T cell number ( J:103485 )
• notable decrease in percentage of CD8+ cells

hematopoietic system
increased B cell number ( J:103485 )
• notable increase in mean percentage of B cells
decreased CD4-positive, alpha-beta T cell number ( J:103485 )
• notable decrease in percentage of CD4+ cells
decreased CD8-positive, alpha-beta T cell number ( J:103485 )
• notable decrease in percentage of CD8+ cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory