Phenotypes associated with this allele

• Allele Symbol: Dao^G181R
• Allele Name: Gly181Arg
• Allele ID: MGI:3528694
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dao^G181R/Dao^G181R	DDY-Dao1^G181R	MGI:3528898

Genotype
MGI:3528898

hm1

• Allelic Composition: Dao^G181R/Dao^G181R
• Genetic Background: DDY-Dao1^G181R

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:95950 )

• a decrease in the severity of behavioral effects induced by the NMDA receptor antagonist MK-801are seen

ataxia ( J:95950 )

• NMDA receptor antagonist MK-801-induced ataxia is less severe in homozygotes compared to wild-type mice

stereotypic behavior ( J:95950 )

• a significant decrease in the severity of NMDA receptor antagonist MK-801-induced stereotypic behaviors is seen compared to wild-type mice, however voluntary locomotor activity is not significantly different

homeostasis/metabolism

abnormal circulating amino acid level ( J:21994 )

• the levels of D-serine and D-alanine are increased about 5- and 8-fold, respectively, in the serum and the levels of glycine, L-glutamate, and taurine are lower in the serum

• glycine levels are also decreased in the brain however, the levels of L-glutamate and L-glutamine are increased in the cerebellum

increased circulating alanine level ( J:21994 )

• the levels of D-alanine are increased about 8-fold in the serum

decreased circulating glutamic acid level ( J:21994 )

• the levels of L-glutamate are lower in the serum

decreased circulating glycine level ( J:21994 )

• glycine levels are lower in the serum

increased circulating serine level ( J:21994 )

• the levels of D-serine are increased about 5-fold in the serum

decreased circulating taurine level ( J:21994 )

• taurine levels are lower in the serum

increased glutamic acid level ( J:21994 )

• the levels of L-glutamate are increased in the cerebellum

increased glutamine level ( J:21994 )

• the levels of L-glutamine are increased in the cerebellum

decreased glycine level ( J:21994 )

• glycine levels are decreased in the brain

nervous system

abnormal synaptic neurotransmitter level ( J:21994 )

• the levels of D-serine and D-alanine are increased in the rostral brain and cerebellum