Phenotypes associated with this allele

• Allele Symbol: Aoc3^tm1Salm
• Allele Name: targeted mutation 1, Marko Salmi
• Allele ID: MGI:3528069
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aoc3^tm1Salm/Aoc3^tm1Salm	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:3528235

Genotype
MGI:3528235

hm1

• Allelic Composition: Aoc3^tm1Salm/Aoc3^tm1Salm
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:95656 )

• the overall efficiency of the extravasation process is reduced to 23% of that in wild-type

• when labeled lymphocytes are transferred into homozygous recipients significantly fewer labeled cells are found in the mesenteric lymph node and spleen compared to wild-type recipients; however, in untreated homozygotes the absolute number of leukocytes in the blood, peripheral lymph nodes, Peyer's patches, mesenteric lymph nodes, and spleen are normal

abnormal cellular extravasation ( J:95656 )

• in highly inflamed cremaster muscle transmigration of polymorphonuclear leukocytes is decreased by 71% (absolute numbers) or 47% (relative to the number of adhered leukocytes)

abnormal leukocyte adhesion ( J:95656 )

• in inflamed cremaster muscle the number of stably bound polymorphonuclear leukocytes is decreased by about 50% and the efficiency of the firm adhesion step is reduced 3.2-fold compared to wild-type; firm adhesion is also impaired in highly inflamed cremaster muscle

• firm adhesion is decreased in Peyer's patches

impaired leukocyte tethering or rolling ( J:95656 )

• the rolling velocity of mutant polymorphonuclear leukocytes is increased about 5-fold compared to wild-type in inflamed cremaster muscle (treated with 500 ng TNF intrascrotally for 3 hours); rolling velocity is also in creased in highly inflamed cremaster muscle (1.5 ug of TNF for 6 hours)

• rolling velocity is increased in Peyer's patches however the number of rolling cells is the same as in wild-type

decreased inflammatory response ( J:95656 )

• a 50% reduction in the number of infiltrating leukocytes is seen in homozygotes 6 hours after induction of peritonitis by a peritoneal injection of TNF

cellular

abnormal leukocyte migration ( J:95656 )

• the overall efficiency of the extravasation process is reduced to 23% of that in wild-type

• when labeled lymphocytes are transferred into homozygous recipients significantly fewer labeled cells are found in the mesenteric lymph node and spleen compared to wild-type recipients; however, in untreated homozygotes the absolute number of leukocytes in the blood, peripheral lymph nodes, Peyer's patches, mesenteric lymph nodes, and spleen are normal

abnormal cellular extravasation ( J:95656 )

• in highly inflamed cremaster muscle transmigration of polymorphonuclear leukocytes is decreased by 71% (absolute numbers) or 47% (relative to the number of adhered leukocytes)

abnormal leukocyte adhesion ( J:95656 )

• in inflamed cremaster muscle the number of stably bound polymorphonuclear leukocytes is decreased by about 50% and the efficiency of the firm adhesion step is reduced 3.2-fold compared to wild-type; firm adhesion is also impaired in highly inflamed cremaster muscle

• firm adhesion is decreased in Peyer's patches

impaired leukocyte tethering or rolling ( J:95656 )

• the rolling velocity of mutant polymorphonuclear leukocytes is increased about 5-fold compared to wild-type in inflamed cremaster muscle (treated with 500 ng TNF intrascrotally for 3 hours); rolling velocity is also in creased in highly inflamed cremaster muscle (1.5 ug of TNF for 6 hours)

• rolling velocity is increased in Peyer's patches however the number of rolling cells is the same as in wild-type

hematopoietic system

abnormal leukocyte migration ( J:95656 )

• the overall efficiency of the extravasation process is reduced to 23% of that in wild-type

• when labeled lymphocytes are transferred into homozygous recipients significantly fewer labeled cells are found in the mesenteric lymph node and spleen compared to wild-type recipients; however, in untreated homozygotes the absolute number of leukocytes in the blood, peripheral lymph nodes, Peyer's patches, mesenteric lymph nodes, and spleen are normal

abnormal cellular extravasation ( J:95656 )

• in highly inflamed cremaster muscle transmigration of polymorphonuclear leukocytes is decreased by 71% (absolute numbers) or 47% (relative to the number of adhered leukocytes)

abnormal leukocyte adhesion ( J:95656 )

• in inflamed cremaster muscle the number of stably bound polymorphonuclear leukocytes is decreased by about 50% and the efficiency of the firm adhesion step is reduced 3.2-fold compared to wild-type; firm adhesion is also impaired in highly inflamed cremaster muscle

• firm adhesion is decreased in Peyer's patches

impaired leukocyte tethering or rolling ( J:95656 )

• the rolling velocity of mutant polymorphonuclear leukocytes is increased about 5-fold compared to wild-type in inflamed cremaster muscle (treated with 500 ng TNF intrascrotally for 3 hours); rolling velocity is also in creased in highly inflamed cremaster muscle (1.5 ug of TNF for 6 hours)

• rolling velocity is increased in Peyer's patches however the number of rolling cells is the same as in wild-type