Analysis Tools
adipose tissue
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• fat pads weigh less than wild-type under normal conditions (no deoxycycline treatment so that Npy is overexpressed)
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growth/size/body
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• body weights, food consumption, and adiposity are no different from wild-type under normal conditions (no deoxycycline treatment)
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• doxycycline treatment to reduce expression of Npy results in a similar decrease in body weight and food consumption during the first few days of doxycycline treatment as in wild-type, however homozygotes take a longer time to recover their body weights than wild-type
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nervous system
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• exhibit decreased sensitivity to kainate-induced seizures under normal conditions (no deoxycycline treatment), with greater latencies to onset of stage 3 and stage 5 seizures and reduced amount of time spent in stages 3, 4, and 5
• deoxycycline treatment for 1 week increases kainate sensitivity such that seizures are no longer different from that in wild-type
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behavior/neurological
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• exhibit decreased sensitivity to kainate-induced seizures under normal conditions (no deoxycycline treatment), with greater latencies to onset of stage 3 and stage 5 seizures and reduced amount of time spent in stages 3, 4, and 5
• deoxycycline treatment for 1 week increases kainate sensitivity such that seizures are no longer different from that in wild-type
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