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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad2tm3Rob
targeted mutation 3, Elizabeth J Robertson
MGI:3527155
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad2tm3Rob/Smad2tm3Rob involves: 129S/SvEv * C57BL/6 * ICR MGI:3527578
cx2
 		Smad2tm3Rob/Smad2tm3Rob
Smad3tm1Xfw/Smad3tm1Xfw 		involves: 129/Sv * 129S/SvEv * C57BL/6 * ICR MGI:3527579


Genotype
MGI:3527578
hm1
Allelic
Composition		 Smad2tm3Rob/Smad2tm3Rob
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm3Rob mutation (2 available); any Smad2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:95374 )
• homozygotes are viable, fertile, and do not display any overt abnormalities through 9 months of age




Genotype
MGI:3527579
cx2
Allelic
Composition		 Smad2tm3Rob/Smad2tm3Rob
Smad3tm1Xfw/Smad3tm1Xfw
Genetic
Background		 involves: 129/Sv * 129S/SvEv * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm3Rob mutation (2 available); any Smad2 mutation (52 available)
Smad3tm1Xfw mutation (0 available); any Smad3 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
osteoarthritis ( J:95374 )
• double homozygotes develop osteoarthritis similar to Smad3 single homozygotes but do not show any increase in mortality

skeleton
osteoarthritis ( J:95374 )
• double homozygotes develop osteoarthritis similar to Smad3 single homozygotes but do not show any increase in mortality




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory