Phenotypes associated with this allele

• Allele Symbol: Schip1^{Gt(ROSA)77Sor}
• Allele Name: gene trapped 77, Philippe Soriano
• Allele ID: MGI:3526869
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Schip1^Gt(ROSA)77Sor/Schip1^Gt(ROSA)77Sor	involves: 129S4/SvJaeSor	MGI:3717117
cx2	Pdgfra^tm1Sor/Pdgfra^+ Schip1^Gt(ROSA)77Sor/Schip1^Gt(ROSA)77Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823020
cx3	Pdgfrb^tm1Sor/Pdgfrb^+ Schip1^Gt(ROSA)77Sor/Schip1^Gt(ROSA)77Sor	involves: 129S4/SvJaeSor * 129S7/SvEvBrd	MGI:3717127

Genotype
MGI:3717117

hm1

• Allelic Composition: Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor}
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:117491 )

• 20% of mice die by week 1

skeleton

abnormal skeleton morphology ( J:117491 )

• abnormal neural crest derived and thoracic skeleton

small presphenoid bone ( J:117491 )

• 25% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

decreased palatine bone horizontal plate size ( J:117491 )

• 25% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal sternum morphology ( J:117491 )

• 42% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum

asymmetric sternocostal joints ( J:117491 )

increased rib number ( J:117491 )

• 33% of mice have a 14th pair of ribs

cellular

decreased fibroblast cell migration ( J:117491 )

• mouse embryonic fibroblast cells show reduced migration in a scratch test in response to PDGF stimulation

craniofacial

small presphenoid bone ( J:117491 )

• 25% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

decreased palatine bone horizontal plate size ( J:117491 )

• 25% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal palatal shelf fusion at midline ( J:117491 )

• irregularities in fusion persist into adulthood

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

digestive/alimentary system

decreased palatine bone horizontal plate size ( J:117491 )

• 25% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal palatal shelf fusion at midline ( J:117491 )

• irregularities in fusion persist into adulthood

growth/size/body

short nasal bone ( J:117491 )

decreased palatine bone horizontal plate size ( J:117491 )

• 25% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal palatal shelf fusion at midline ( J:117491 )

• irregularities in fusion persist into adulthood

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

respiratory system

short nasal bone ( J:117491 )

Genotype
MGI:3823020

cx2

• Allelic Composition: Pdgfra^tm1Sor/Pdgfra⁺; Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

reproductive system

abnormal ovary morphology ( J:142042 )

♀ • ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

♀ • reduction in numbers of vascular smooth muscle cells in the ovaries

decreased corpora lutea number ( J:142042 )

♀ • number and incidence of corpora lutea are reduced

decreased tertiary ovarian follicle number ( J:142042 )

♀ • decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

♀ • reduction in theca cells

small ovary ( J:142042 )

♀

uterus hypoplasia ( J:142042 )

♀ • uterus is hypoplastic, with major uterine layers present but underdeveloped

anovulation ( J:142042 )

♀ • little or no ovulation

female infertility ( J:142042 )

♀ • 45% of females are sterile

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

endocrine/exocrine glands

abnormal ovary morphology ( J:142042 )

♀ • ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

♀ • reduction in numbers of vascular smooth muscle cells in the ovaries

decreased corpora lutea number ( J:142042 )

♀ • number and incidence of corpora lutea are reduced

decreased tertiary ovarian follicle number ( J:142042 )

♀ • decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

♀ • reduction in theca cells

small ovary ( J:142042 )

♀

cardiovascular system

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

muscle

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

Genotype
MGI:3717127

cx3

• Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺; Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor}
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in Schip1^{Gt(ROSA)77Sor} homozygotes

renal/urinary system

abnormal renal glomerulus morphology ( J:117491 )

• glomeruli are often swollen and degraded

• smooth muscle cell number is reduced in the glomeruli

abnormal kidney physiology ( J:117491 )

• decrease in kidney function

homeostasis/metabolism

increased blood urea nitrogen level ( J:117491 )

muscle

abnormal smooth muscle morphology ( J:117491 )

• smooth muscle cell number is reduced in the glomeruli