Phenotypes associated with this allele

• Allele Symbol: Zfp640^{Gt(ROSA)81Sor}
• Allele Name: gene trapped 81, Philippe Soriano
• Allele ID: MGI:3526867
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp640^Gt(ROSA)81Sor/Zfp640^Gt(ROSA)81Sor	involves: 129S4/SvJaeSor	MGI:3717115

Genotype
MGI:3717115

hm1

• Allelic Composition: Zfp640^{Gt(ROSA)81Sor}/Zfp640^{Gt(ROSA)81Sor}
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal skeleton morphology ( J:117491 )

• abnormal neural crest derived and thoracic skeleton

small presphenoid bone ( J:117491 )

• 35% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

decreased palatine bone horizontal plate size ( J:117491 )

• 35% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal sternum morphology ( J:117491 )

• 20% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum

asymmetric sternocostal joints ( J:117491 )

increased rib number ( J:117491 )

• 20% of mice have a 14th pair of ribs

abnormal vertebrae morphology ( J:117491 )

• 10% of mice have widened vertebral arches and forked vertebrae

abnormal vertebral arch morphology ( J:117491 )

• 10% of mice have widened vertebral arches and forked vertebrae

growth/size/body

decreased palatine bone horizontal plate size ( J:117491 )

• 35% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal palatal shelf fusion at midline ( J:117491 )

• irregularities in fusion persist into adulthood

increased body weight ( J:117491 )

• in males following adolescence

cellular

decreased fibroblast cell migration ( J:117491 )

• mouse embryonic fibroblast cells show reduced migration in a scratch test in response to PDGF stimulation

craniofacial

small presphenoid bone ( J:117491 )

• 35% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

decreased palatine bone horizontal plate size ( J:117491 )

• 35% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal palatal shelf fusion at midline ( J:117491 )

• irregularities in fusion persist into adulthood

digestive/alimentary system

decreased palatine bone horizontal plate size ( J:117491 )

• 35% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal palatal shelf fusion at midline ( J:117491 )

• irregularities in fusion persist into adulthood