Phenotypes associated with this allele

• Allele Symbol: Myo1e^{Gt(ROSA)74Sor}
• Allele Name: gene trapped 74, Philippe Soriano
• Allele ID: MGI:3526864
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo1e^Gt(ROSA)74Sor/Myo1e^Gt(ROSA)74Sor	involves: 129S4/SvJaeSor	MGI:3717114
cx2	Myo1e^Gt(ROSA)74Sor/Myo1e^Gt(ROSA)74Sor Pdgfra^tm2Sor/Pdgfra^+	involves: 129S4/SvJaeSor	MGI:3717131
cx3	Myo1e^Gt(ROSA)74Sor/Myo1e^Gt(ROSA)74Sor Pdgfrb^tm1Sor/Pdgfrb^+	involves: 129S4/SvJaeSor * 129S7/SvEvBrd	MGI:3717126

Genotype
MGI:3717114

hm1

• Allelic Composition: Myo1e^{Gt(ROSA)74Sor}/Myo1e^{Gt(ROSA)74Sor}
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:117491 )

• fewer mice (15%) are born than expected (25%)

cardiovascular system

abnormal blood vessel morphology ( J:117491 )

hemorrhage ( J:117491 )

• at E11.5-E18.5

hematopoietic system

anemia ( J:117491 )

• by week 6

decreased erythrocyte cell number ( J:117491 )

• by week 6

decreased hematocrit ( J:117491 )

• by week 6

decreased hemoglobin content ( J:117491 )

• by week 6

polychromatophilia ( J:117491 )

reticulocytosis ( J:117491 )

• an increase in immature red blood cells is observed compared to wild-type mice

Genotype
MGI:3717131

cx2

• Allelic Composition: Myo1e^{Gt(ROSA)74Sor}/Myo1e^{Gt(ROSA)74Sor}; Pdgfra^tm2Sor/Pdgfra⁺
• Genetic Background: involves: 129S4/SvJaeSor

hematopoietic system

anemia ( J:117491 )

• anemia is less severe than in Myo1e^{Gt(ROSA)74Sor} homozygotes

Genotype
MGI:3717126

cx3

• Allelic Composition: Myo1e^{Gt(ROSA)74Sor}/Myo1e^{Gt(ROSA)74Sor}; Pdgfrb^tm1Sor/Pdgfrb⁺
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

hematopoietic system

hematopoietic system phenotype ( J:117491 )

N • anemia seen in Myo1e^{Gt(ROSA)74Sor} is rescued

renal/urinary system

abnormal renal glomerulus morphology ( J:117491 )

• glomeruli are often swollen and degraded

• smooth muscle cell number is reduced in the glomeruli

abnormal kidney physiology ( J:117491 )

• decrease in kidney function

muscle

abnormal smooth muscle morphology ( J:117491 )

• smooth muscle cell number is reduced in the glomeruli

homeostasis/metabolism

increased blood urea nitrogen level ( J:117491 )