All Phenotypes 2610005L07Rik<Gt(ROSA)73Sor> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

2610005L07Rik^{Gt(ROSA)73Sor}
gene trapped 73, Philippe Soriano
MGI:3526861

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor}	involves: 129S4/SvJaeSor	MGI:3717112
cx2	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor} Pdgfra^tm1Sor/Pdgfra⁺	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823024
cx3	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor} Pdgfra^tm2Sor/Pdgfra⁺	involves: 129S4/SvJaeSor	MGI:3717137

Allelic Composition	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor}
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2610005L07Rik^{Gt(ROSA)73Sor} mutation (1 available); any 2610005L07Rik mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:117491 )

• fewer mice (9%) are born than expected (25%)

skeleton

abnormal skeleton morphology ( J:117491 )

• abnormal neural crest derived and thoracic skeleton

abnormal neurocranium morphology ( J:117491 )

• 100% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

abnormal sternum morphology ( J:117491 )

• 40% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum

asymmetric sternocostal joints ( J:117491 )

cellular

increased fibroblast cell migration ( J:117491 )

• mouse embryonic fibroblast cells show increased migration in a scratch test in response to PDGF stimulation

craniofacial

abnormal neurocranium morphology ( J:117491 )

• 100% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

growth/size/body

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

respiratory system

short nasal bone ( J:117491 )

Allelic Composition	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor} Pdgfra^tm1Sor/Pdgfra⁺
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2610005L07Rik^{Gt(ROSA)73Sor} mutation (1 available); any 2610005L07Rik mutation (13 available)
Pdgfra^tm1Sor mutation (0 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal ovary morphology ( J:142042 )

• ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

• reduction in numbers of vascular smooth muscle cells in the ovaries

decreased corpora lutea number ( J:142042 )

• number and incidence of corpora lutea are reduced

decreased tertiary ovarian follicle number ( J:142042 )

• decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

• reduction in theca cells

small ovary ( J:142042 )

uterus hypoplasia ( J:142042 )

• uterus is hypoplastic, with major uterine layers present but underdeveloped

anovulation ( J:142042 )

• little or no ovulation

female infertility ( J:142042 )

• 35% of females are sterile

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

endocrine/exocrine glands

abnormal ovary morphology ( J:142042 )

• ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

• reduction in numbers of vascular smooth muscle cells in the ovaries

decreased corpora lutea number ( J:142042 )

• number and incidence of corpora lutea are reduced

decreased tertiary ovarian follicle number ( J:142042 )

• decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

• reduction in theca cells

small ovary ( J:142042 )

cardiovascular system

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

muscle

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

Allelic Composition	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor} Pdgfra^tm2Sor/Pdgfra⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2610005L07Rik^{Gt(ROSA)73Sor} mutation (1 available); any 2610005L07Rik mutation (13 available)
Pdgfra^tm2Sor mutation (0 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

short snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

growth/size/body

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

short snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

respiratory system

short nasal bone ( J:117491 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23