Analysis Tools
mortality/aging
|
• mice die within hours of birth
|
skeleton
|
• abnormal neural crest derived and thoracic skeleton
|
|
• 20% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones
|
|
• increases in the gaps between frontal bones
|
|
• 20% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum
|
craniofacial
|
• 20% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones
|
|
• increases in the gaps between frontal bones
|
cardiovascular system
hemorrhage
(
J:117491
)
|
• at E18.5
|
|
• at E18.5-E19.5
|
respiratory system
|
• at E18.5
|
|
• at birth mice have difficulty breathing
|
muscle
cellular
|
• mouse embryonic fibroblast cells show reduced migration in a scratch test in response to PDGF stimulation
|
homeostasis/metabolism
|
• at E18.5
|
