All Phenotypes Sgpl1<Gt(ROSA)78Sor> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823005
hm2	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	MGI:3717119
hm3	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor * C57BL/6	MGI:5440333
cx4	Pdgfrb^tm1Sor/Pdgfrb⁺ Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)	MGI:3823018
cx5	Pdgfra^tm1Sor/Pdgfra⁺ Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823017

Allelic Composition	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgpl1^{Gt(ROSA)78Sor} mutation (1 available); any Sgpl1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

multinucleated giant male germ cells ( J:142042 )

• at P42, multinucleated giant cells are seen throughout testis cords

abnormal ovary morphology ( J:142042 )

• ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

• reduction in numbers of vascular smooth muscle cells in the ovaries

absent corpus luteum ( J:142042 )

decreased tertiary ovarian follicle number ( J:142042 )

• decreased numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

• reduction in theca cells

small ovary ( J:142042 )

abnormal testis morphology ( J:142042 )

• testis morphology appears normal at P7, but by P20 mutants show a reduction in the testis interstitium

abnormal testis cord formation ( J:142042 )

• by p20, mutants exhibit gaps in the spermatocyte layers of the testis cords

• at P42, multinucleated giant cells are seen throughout testis cords

decreased Leydig cell number ( J:142042 )

• reduction in Leydig cells before and during early adolescence (P7, P14, P21)

small testis ( J:142042 )

• reduction in testis size is observed by P42

uterus hypoplasia ( J:142042 )

• uterus is hypoplastic, with major uterine layers present but underdeveloped

abnormal spermatogenesis ( J:142042 )

• at P42, spermatogenesis is absent

abnormal spermatid morphology ( J:142042 )

• at P42, spermatids are absent

abnormal spermatocyte morphology ( J:142042 )

• loss of spermatocytes from the testis cords by P42

anovulation ( J:142042 )

• little or no ovulation

female infertility ( J:142042 )

male infertility ( J:142042 )

cardiovascular system

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

abnormal testosterone level ( J:142042 )

• decrease in testosterone levels in testis

decreased circulating testosterone level ( J:142042 )

• decrease in testosterone levels in serum and testis

endocrine/exocrine glands

abnormal ovary morphology ( J:142042 )

• ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

• reduction in numbers of vascular smooth muscle cells in the ovaries

absent corpus luteum ( J:142042 )

decreased tertiary ovarian follicle number ( J:142042 )

• decreased numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

• reduction in theca cells

small ovary ( J:142042 )

abnormal testis morphology ( J:142042 )

• testis morphology appears normal at P7, but by P20 mutants show a reduction in the testis interstitium

abnormal testis cord formation ( J:142042 )

• by p20, mutants exhibit gaps in the spermatocyte layers of the testis cords

• at P42, multinucleated giant cells are seen throughout testis cords

decreased Leydig cell number ( J:142042 )

• reduction in Leydig cells before and during early adolescence (P7, P14, P21)

small testis ( J:142042 )

• reduction in testis size is observed by P42

cellular

abnormal spermatid morphology ( J:142042 )

• at P42, spermatids are absent

abnormal spermatocyte morphology ( J:142042 )

• loss of spermatocytes from the testis cords by P42

multinucleated giant male germ cells ( J:142042 )

• at P42, multinucleated giant cells are seen throughout testis cords

muscle

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:117491 )

• all mice die by 8 weeks

skeleton

abnormal skeleton morphology ( J:117491 )

• abnormal neural crest derived and thoracic skeleton

abnormal neurocranium morphology ( J:117491 )

• 75% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

small presphenoid bone ( J:117491 )

• 75% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

decreased palatine bone horizontal plate size ( J:117491 )

• 75% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal sternum morphology ( J:117491 )

• 50% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum

asymmetric sternocostal joints ( J:117491 )

abnormal vertebrae morphology ( J:117491 )

• 20% of mice have widened vertebral arches and forked vertebrae

abnormal vertebral arch morphology ( J:117491 )

• 20% of mice have widened vertebral arches and forked vertebrae

renal/urinary system

abnormal kidney morphology ( J:117491 )

podocyte foot process effacement ( J:242932 )

• kidneys exhibit complete podocyte foot effacement

absent podocyte slit diaphragm ( J:242932 )

abnormal renal glomerulus morphology ( J:117491 )

• glomeruli are often degraded

• smooth muscle cell number is reduced in the glomeruli

• migration of smooth muscle cells in glomeruli is impaired

small kidney ( J:117491 )

pale kidney ( J:117491 )

abnormal kidney physiology ( J:117491 )

• decrease in kidney function

kidney inflammation ( J:117491 )

• kidney is swollen in sections and blood filled

hematopoietic system

anemia ( J:117491 )

• by week 6

decreased erythrocyte cell number ( J:117491 )

• by week 6

decreased hematocrit ( J:117491 )

• by week 6

decreased hemoglobin content ( J:117491 )

• by week 6

polychromatophilia ( J:117491 )

reticulocytosis ( J:117491 )

• an increase in immature red blood cells is observed compared to wild-type mice

growth/size/body

decreased palatine bone horizontal plate size ( J:117491 )

• 75% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal palatal shelf fusion at midline ( J:117491 )

• irregularities in fusion persist into adulthood

decreased body weight ( J:117491 )

postnatal growth retardation ( J:117491 )

cellular

abnormal cell migration ( J:117491 )

• migration of smooth muscle cells in glomeruli is impaired

decreased fibroblast cell migration ( J:117491 )

• mouse embryonic fibroblast cells show reduced migration in a scratch test in response to PDGF stimulation

homeostasis/metabolism

increased blood urea nitrogen level ( J:117491 )

decreased circulating serum albumin level ( J:242932 )

cardiovascular system

abnormal blood vessel morphology ( J:117491 )

hemorrhage ( J:117491 )

• at E11.5-E18.5

muscle

abnormal smooth muscle morphology ( J:117491 )

• smooth muscle cell number is reduced in the glomeruli

immune system

kidney inflammation ( J:117491 )

• kidney is swollen in sections and blood filled

craniofacial

abnormal neurocranium morphology ( J:117491 )

• 75% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

small presphenoid bone ( J:117491 )

• 75% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

decreased palatine bone horizontal plate size ( J:117491 )

• 75% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal palatal shelf fusion at midline ( J:117491 )

• irregularities in fusion persist into adulthood

digestive/alimentary system

decreased palatine bone horizontal plate size ( J:117491 )

• 75% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal palatal shelf fusion at midline ( J:117491 )

• irregularities in fusion persist into adulthood

Allelic Composition	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgpl1^{Gt(ROSA)78Sor} mutation (1 available); any Sgpl1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased lymphocyte cell number ( J:187619 )

abnormal immune system physiology ( J:187619 )

abnormal leukocyte migration ( J:187619 )

• neutrophile trafficking defects

abnormal T cell physiology ( J:187619 )

• mature T cells are retained in the thymus

hematopoietic system

abnormal leukocyte migration ( J:187619 )

• neutrophile trafficking defects

decreased lymphocyte cell number ( J:187619 )

abnormal T cell physiology ( J:187619 )

• mature T cells are retained in the thymus

cellular

abnormal leukocyte migration ( J:187619 )

• neutrophile trafficking defects

Allelic Composition	Pdgfrb^tm1Sor/Pdgfrb⁺ Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm1Sor mutation (1 available); any Pdgfrb mutation (84 available)
Sgpl1^{Gt(ROSA)78Sor} mutation (1 available); any Sgpl1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:142042 )

male infertility ( J:142042 )

Allelic Composition	Pdgfra^tm1Sor/Pdgfra⁺ Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm1Sor mutation (0 available); any Pdgfra mutation (85 available)
Sgpl1^{Gt(ROSA)78Sor} mutation (1 available); any Sgpl1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:142042 )

male infertility ( J:142042 )

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