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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmox1tm1Ysh
targeted mutation 1, Ye-Shih Ho
MGI:3526703
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hmox1tm1Ysh/Hmox1tm1Ysh involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3526729
ht2
 		Hmox1tm1Ysh/Hmox1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3526730


Genotype
MGI:3526729
hm1
Allelic
Composition		 Hmox1tm1Ysh/Hmox1tm1Ysh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmox1tm1Ysh mutation (0 available); any Hmox1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:95461 )
• no homozygous mice were detected, indicating embryonic lethality




Genotype
MGI:3526730
ht2
Allelic
Composition		 Hmox1tm1Ysh/Hmox1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmox1tm1Ysh mutation (0 available); any Hmox1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
myocardium necrosis ( J:95461 )
• significantly higher myocardial necrosis after ischemia than in wild-type
abnormal cardiovascular system physiology ( J:95461 )
• increased release of creatine kinase and production of malonaldehyde (MDA) in the heart during reperfusion compared to wild-type
abnormal cardiac muscle contractility ( J:95461 )
• significantly lower contractile recovery after 30 minutes of ischemia
• the force developed by the heart (DF) during reperfusion was lower than in wild-type and did not recover beyond 87% of baseline
• preconditioning, which renders the heart tolerant to subsequent ischemia/reperfusion, did not result in an improvement in contractile recovery after injury as in wild-type
increased myocardial infarct size ( J:95461 )
• infarct size was significantly higher (48.5%) than in wild-type (28.5%) after ischemia/reperfusion

muscle
myocardium necrosis ( J:95461 )
• significantly higher myocardial necrosis after ischemia than in wild-type
abnormal cardiac muscle contractility ( J:95461 )
• significantly lower contractile recovery after 30 minutes of ischemia
• the force developed by the heart (DF) during reperfusion was lower than in wild-type and did not recover beyond 87% of baseline
• preconditioning, which renders the heart tolerant to subsequent ischemia/reperfusion, did not result in an improvement in contractile recovery after injury as in wild-type

homeostasis/metabolism
increased myocardial infarct size ( J:95461 )
• infarct size was significantly higher (48.5%) than in wild-type (28.5%) after ischemia/reperfusion

cellular
myocardium necrosis ( J:95461 )
• significantly higher myocardial necrosis after ischemia than in wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory