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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aif1tm1Nsib
targeted mutation 1, Nicholas Sibinga
MGI:3526421
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aif1tm1Nsib/Aif1tm1Nsib involves: 129S/SvEv * C57BL/6 MGI:5547994


Genotype
MGI:5547994
hm1
Allelic
Composition		 Aif1tm1Nsib/Aif1tm1Nsib
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aif1tm1Nsib mutation (0 available); any Aif1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased spleen weight ( J:204462 )
• without a change in cell density
decreased susceptibility to induced arthritis ( J:204462 )
• in a collagen-induced arthritis model, mice exhibit reduced paw thickening and disease score compared with wild-type mice

skeleton
decreased susceptibility to induced arthritis ( J:204462 )
• in a collagen-induced arthritis model, mice exhibit reduced paw thickening and disease score compared with wild-type mice

hematopoietic system
decreased spleen weight ( J:204462 )
• without a change in cell density




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory