All Phenotypes Megf10<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Megf10⁺
wild type
MGI:3526404

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Megf10^{tm1(KOMP)Vlcg}/Megf10⁺	C57BL/6N-Megf10^{tm1(KOMP)Vlcg}	MGI:5792949
ht2	Megf10^{tm1a(KOMP)Jrs}/Megf10⁺	involves: 129S4/SvJae * C57BL/6	MGI:5320417

Allelic Composition	Megf10^{tm1(KOMP)Vlcg}/Megf10⁺
Genetic Background	C57BL/6N-Megf10^{tm1(KOMP)Vlcg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf10^{tm1(KOMP)Vlcg} mutation (1 available); any Megf10 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased hindbrain apoptosis ( J:231811 )

• increase in apoptotic cells specifically in the cerebellum at P7 but not in the adult cerebellum

abnormal astrocyte physiology ( J:231811 )

• cultured astrocytes show impaired engulfment of UV-irradiated apoptotic MEFs, with an approximate 60% reduction in engulfment compared to wild-type astrocytes indicating impaired phagocytosis of apoptotic cells

nervous system

increased hindbrain apoptosis ( J:231811 )

• increase in apoptotic cells specifically in the cerebellum at P7 but not in the adult cerebellum

abnormal astrocyte physiology ( J:231811 )

abnormal cerebellum morphology ( J:231811 )

• increase in apoptotic cells specifically in the cerebellum at P7 but not in the adult cerebellum

Allelic Composition	Megf10^{tm1a(KOMP)Jrs}/Megf10⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf10^{tm1a(KOMP)Jrs} mutation (1 available); any Megf10 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal amacrine cell morphology ( J:182578 )

• starburst amacrine cells arrays are mildly disorganized compared to in wild-type mice

vision/eye

abnormal amacrine cell morphology ( J:182578 )

• starburst amacrine cells arrays are mildly disorganized compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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