About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zap70st
strange
MGI:3526403
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zap70st/Zap70st involves: C57BL/6 MGI:3526699
ht2
 		Zap70st/Zap70tm1Dlo involves: C57BL/6 MGI:3526700


Genotype
MGI:3526699
hm1
Allelic
Composition		 Zap70st/Zap70st
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70st mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested T cell differentiation ( J:41170 )
• thymocytes fail to mature beyond the double positive stage
decreased T cell number ( J:41170 )
• no single positive T cells are seen in spleen and lymph nodes
abnormal T cell physiology ( J:41170 )
• antibody induced co-cross-linking of surface T cell receptors and CD4 failed to mobilize intracellular calcium in mutant T cells unlike in wild-type cells

immune system
arrested T cell differentiation ( J:41170 )
• thymocytes fail to mature beyond the double positive stage
decreased T cell number ( J:41170 )
• no single positive T cells are seen in spleen and lymph nodes
abnormal T cell physiology ( J:41170 )
• antibody induced co-cross-linking of surface T cell receptors and CD4 failed to mobilize intracellular calcium in mutant T cells unlike in wild-type cells

endocrine/exocrine glands




Genotype
MGI:3526700
ht2
Allelic
Composition		 Zap70st/Zap70tm1Dlo
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70st mutation (0 available); any Zap70 mutation (55 available)
Zap70tm1Dlo mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested T cell differentiation ( J:41170 )
• thymocytes fail to mature beyond the double positive stage

immune system
arrested T cell differentiation ( J:41170 )
• thymocytes fail to mature beyond the double positive stage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory