Phenotypes associated with this allele

• Allele Symbol: Rad9b^tm1Lieb
• Allele Name: targeted mutation 1, Howard B Lieberman
• Allele ID: MGI:3526236
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad9b^tm1Lieb/Rad9b^tm1Lieb	involves: 129S6/SvEvTac * C57BL/6J	MGI:4837939
ht2	Rad9b^tm1Lieb/Rad9b^+	involves: 129S6/SvEvTac * C57BL/6J	MGI:4837940

Genotype
MGI:4837939

hm1

• Allelic Composition: Rad9b^tm1Lieb/Rad9b^tm1Lieb
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:165426 )

• mice die between E8.5 and E11.5

nervous system

abnormal forebrain development ( J:165426 )

• at E9.5, proliferation of cells in the forebrain mesenchyme and neuroepithelium is decreased compared to in wild-type mice

embryo

embryonic growth arrest ( J:165426 )

embryonic growth retardation ( J:165426 )

• at E9.5, mice exhibit developmental delay compared with wild-type mice

decreased embryo size ( J:165426 )

• at E9.5

impaired somite development ( J:165426 )

• at E9.5, proliferation in somites is decreased compared to in wild-type mice

cellular

cellular phenotype ( J:165426 )

N • ES cells exhibit normal G2/M cell cycle checkpoint control and genomic integrity

increased sensitivity to induced cell death ( J:165426 )

• ES cells are more sensitive than wild-type cells to gamma irradiation and mitomycin C

• however, sensitivity to cisplatic, ethyl methanesulfonate, and hydroxyurea

increased cellular sensitivity to gamma-irradiation ( J:165426 )

• in ES cells

early cellular replicative senescence ( J:165426 )

• mouse embryonic fibroblasts stop growing and start dying after one replating unlike wild-type cells

growth/size/body

embryonic growth retardation ( J:165426 )

• at E9.5, mice exhibit developmental delay compared with wild-type mice

decreased embryo size ( J:165426 )

• at E9.5

Genotype
MGI:4837940

ht2

• Allelic Composition: Rad9b^tm1Lieb/Rad9b⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:165426 )

• some mice die between E12.5 and up to a few days after birth

postnatal lethality, incomplete penetrance ( J:165426 )

• some mice die between E12.5 and up to a few days after birth

embryonic lethality during organogenesis, incomplete penetrance ( J:165426 )

• some mice die between E12.5 and up to a few days after birth

embryo

abnormal embryo development ( J:165426 )

• mice exhibit a developmental defect rather than uniform developmental delay

decreased embryo size ( J:165426 )

• at E8.5

open neural tube ( J:165426 )

• in 2 of 21 mice at E9.5

• in 5 of 16 mice at E10.5

impaired somite development ( J:165426 )

• mice exhibit abnormal somite development with numbers of somites ranging from 0 to 11 unlike in wild-type mice

nervous system

open neural tube ( J:165426 )

• in 2 of 21 mice at E9.5

• in 5 of 16 mice at E10.5

abnormal forebrain development ( J:165426 )

• at E9.5, proliferation of forebrain neuroepithelium is increased compared to in wild-type mice

cellular

increased sensitivity to induced cell death ( J:165426 )

• one clone of ES cells is more sensitive than wild-type cells to gamma irradiation and mitomycin C

increased cellular sensitivity to gamma-irradiation ( J:165426 )

• in one clone of ES cells

growth/size/body

decreased embryo size ( J:165426 )

• at E8.5