Phenotypes associated with this allele

• Allele Symbol: Plcl1^tm1Mh
• Allele Name: targeted mutation 1, Masato Hirata
• Allele ID: MGI:3526123
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plcl1^tm1Mh/Plcl1^tm1Mh	involves: 129/Sv * C57BL/6	MGI:3526813
hm2	Plcl1^tm1Mh/Plcl1^tm1Mh	involves: C57BL/6	MGI:3526259

Genotype
MGI:3526813

hm1

• Allelic Composition: Plcl1^tm1Mh/Plcl1^tm1Mh
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:92956 )

• increased mortality rate after PTZ (at 56 mg/kg) induced seizures compared to wild-type

behavior/neurological

seizures ( J:92956 )

• mutants do not develop spontaneous behavior seizure

increased susceptibility to pharmacologically induced seizures ( J:92956 )

• homozygous mutants were more susceptible to pentylenetetrazol (PTZ) induced convulsion

• homozygous mutants have shorter latencies until the first clonic convulsion and tonic extensor and increased incidence of convulsion than wild-type following PTZ administration

nervous system

seizures ( J:92956 )

• mutants do not develop spontaneous behavior seizure

increased susceptibility to pharmacologically induced seizures ( J:92956 )

• homozygous mutants were more susceptible to pentylenetetrazol (PTZ) induced convulsion

• homozygous mutants have shorter latencies until the first clonic convulsion and tonic extensor and increased incidence of convulsion than wild-type following PTZ administration

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:92956 )

• increased mortality rate after PTZ (at 56 mg/kg) induced seizures compared to wild-type

Genotype
MGI:3526259

hm2

• Allelic Composition: Plcl1^tm1Mh/Plcl1^tm1Mh
• Genetic Background: involves: C57BL/6

behavior/neurological

impaired behavioral response to xenobiotic ( J:92489 )

• at low doses (1 mg/kg) diazepam does not induce a sedative effect in homozygous mutants, however at high doses (3.2 mg/kg) a sedative effect is seen in mutants and wild-type mice

abnormal motor coordination/balance ( J:92489 )

• mutants fall more often and earlier in a rotarod test

nervous system

abnormal nervous system electrophysiology ( J:92489 )

• Zn²⁺ fails to inhibit and diazepam fails to potentiate GABA_A receptor-mediated Cl^- currents in mutant hippocampal neurons unlike in wild-type