All Phenotypes Nova2<tm1Rbd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nova2^tm1Rbd
targeted mutation 1, Robert B Darnell
MGI:3526014

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nova2^tm1Rbd/Nova2^tm1Rbd	involves: 129	MGI:3694453

Allelic Composition	Nova2^tm1Rbd/Nova2^tm1Rbd
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nova2^tm1Rbd mutation (0 available); any Nova2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:115195 )

• homozygotes live 2-3 weeks after birth

nervous system

abnormal inhibitory postsynaptic currents ( J:115195 )

• homozygotes exhibit no pairing-induced potentiation of small inhibitory postsynaptic currents (mIPSC)

abnormal long-term potentiation ( J:115195 )

• mutants exhibit no pairing-induced long term potentiation (LTP) of the sIPSC at ~20 minutes after pairing; however, induction of LTP of the EPSC is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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