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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fezf2tm1Skm
targeted mutation 1, Susan K McConnell
MGI:3525887
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fezf2tm1Skm/Fezf2tm1Skm involves: 129 MGI:5140797
hm2
 		Fezf2tm1Skm/Fezf2tm1Skm involves: 129 * CD-1 MGI:3611926
cx3
 		Ephb1tm1Dgen/Ephb1+
Fezf2tm1Skm/Fezf2tm1Skm 		involves: 129 MGI:5767283
cx4
 		Ephb1tm1Dgen/Ephb1tm1Dgen
Fezf2tm1Skm/Fezf2+ 		involves: 129 MGI:5767284
cx5
 		Fezf1tm1.1Bche/Fezf1tm1.1Bche
Fezf2tm1Skm/Fezf2tm1Skm 		involves: 129 * CD-1 MGI:5140795
cx6
 		Fezf1tm1.1Bche/Fezf1+
Fezf2tm1Skm/Fezf2tm1Skm 		involves: 129 * CD-1 MGI:5140796


Genotype
MGI:5140797
hm1
Allelic
Composition		 Fezf2tm1Skm/Fezf2tm1Skm
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf2tm1Skm mutation (0 available); any Fezf2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal vomeronasal organ morphology ( J:174726 )
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
• the vomeronasal organ exhibits a 1.5-fold decrease in proliferation and a 1.9-fold increase in cell death compared to in wild-type mice
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice

craniofacial
abnormal vomeronasal organ morphology ( J:174726 )
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
• the vomeronasal organ exhibits a 1.5-fold decrease in proliferation and a 1.9-fold increase in cell death compared to in wild-type mice
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice

respiratory system
abnormal vomeronasal organ morphology ( J:174726 )
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
• the vomeronasal organ exhibits a 1.5-fold decrease in proliferation and a 1.9-fold increase in cell death compared to in wild-type mice
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice

growth/size/body
abnormal vomeronasal organ morphology ( J:174726 )
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
• the vomeronasal organ exhibits a 1.5-fold decrease in proliferation and a 1.9-fold increase in cell death compared to in wild-type mice
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice




Genotype
MGI:3611926
hm2
Allelic
Composition		 Fezf2tm1Skm/Fezf2tm1Skm
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf2tm1Skm mutation (0 available); any Fezf2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:103829 )
• more PLAP-labeled axons enter the thalamus, external capsule, and anterior commissure, while fewer labeled axons are seen in the caudal cerebral peduncle, few or no labeled axons are found in the pyramidal tract, and no labeled axons are seen in the corticospinal tract
• PLAP-labeled axons fail to cross the midline and instead accumulate into Probst bundles or turn ventrally into septum
• most cortical layer 5 neurons fail to extend axons into subcortical targets and neurons from the somatosensory and visual cortex extend fewer axons into the superior colliculus and no axons into the pyramidal decussation or corticospinal tract
abnormal cerebral cortex morphology ( J:103829 )
• expression patterns suggest abnormalities in neurons in layers 5 and 6
abnormal axon morphology ( J:103829 )
• fasciculation of PLAP-labeled axons in the internal capsule is disorganized

cellular
abnormal axon guidance ( J:103829 )
• more PLAP-labeled axons enter the thalamus, external capsule, and anterior commissure, while fewer labeled axons are seen in the caudal cerebral peduncle, few or no labeled axons are found in the pyramidal tract, and no labeled axons are seen in the corticospinal tract
• PLAP-labeled axons fail to cross the midline and instead accumulate into Probst bundles or turn ventrally into septum
• most cortical layer 5 neurons fail to extend axons into subcortical targets and neurons from the somatosensory and visual cortex extend fewer axons into the superior colliculus and no axons into the pyramidal decussation or corticospinal tract




Genotype
MGI:5767283
cx3
Allelic
Composition		 Ephb1tm1Dgen/Ephb1+
Fezf2tm1Skm/Fezf2tm1Skm
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Dgen mutation (0 available); any Ephb1 mutation (42 available)
Fezf2tm1Skm mutation (0 available); any Fezf2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:214959 )
• at P7, PLAP-positive axons inappropriately project through the anterior commissure, unlike in wild-type brains
• no PLAP-positive axons are found in the cerebral peduncle or spinal cord

cellular
abnormal axon guidance ( J:214959 )
• at P7, PLAP-positive axons inappropriately project through the anterior commissure, unlike in wild-type brains
• no PLAP-positive axons are found in the cerebral peduncle or spinal cord




Genotype
MGI:5767284
cx4
Allelic
Composition		 Ephb1tm1Dgen/Ephb1tm1Dgen
Fezf2tm1Skm/Fezf2+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Dgen mutation (0 available); any Ephb1 mutation (42 available)
Fezf2tm1Skm mutation (0 available); any Fezf2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:214959 )
• at P7, a large proportion of PLAP-positive axons extended aberrantly to contralateral targets, crossing the midline via an enlarged anterior commissure, unlike in control mice where PLAP-positive axons are exclusively observed extending along ipsilateral, corticofugal trajectories
• a reduction of PLAP-positive axons is found in the cerebral peduncle and the cervical spinal cord, canonical targets of the corticospinal tract in wild-type mice
increased anterior commissure size ( J:214959 )
• enlarged anterior commissure at P7

cellular
abnormal axon guidance ( J:214959 )
• at P7, a large proportion of PLAP-positive axons extended aberrantly to contralateral targets, crossing the midline via an enlarged anterior commissure, unlike in control mice where PLAP-positive axons are exclusively observed extending along ipsilateral, corticofugal trajectories
• a reduction of PLAP-positive axons is found in the cerebral peduncle and the cervical spinal cord, canonical targets of the corticospinal tract in wild-type mice




Genotype
MGI:5140795
cx5
Allelic
Composition		 Fezf1tm1.1Bche/Fezf1tm1.1Bche
Fezf2tm1Skm/Fezf2tm1Skm
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf1tm1.1Bche mutation (1 available); any Fezf1 mutation (31 available)
Fezf2tm1Skm mutation (0 available); any Fezf2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
abnormal olfactory sensory neuron morphology ( J:174726 )
• as in Fezf1tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

craniofacial
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
abnormal olfactory sensory neuron morphology ( J:174726 )
• as in Fezf1tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

respiratory system
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
abnormal olfactory sensory neuron morphology ( J:174726 )
• as in Fezf1tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:174726 )
• as in Fezf1tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

growth/size/body
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
abnormal olfactory sensory neuron morphology ( J:174726 )
• as in Fezf1tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice




Genotype
MGI:5140796
cx6
Allelic
Composition		 Fezf1tm1.1Bche/Fezf1+
Fezf2tm1Skm/Fezf2tm1Skm
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf1tm1.1Bche mutation (1 available); any Fezf1 mutation (31 available)
Fezf2tm1Skm mutation (0 available); any Fezf2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice

craniofacial
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice

respiratory system
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice

growth/size/body
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory