Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh2Gt(OST49160)Lex mutation
(1 available);
any
Cdh2 mutation
(50 available)
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mortality/aging
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• embryonic lethality as seen in homozygous null Cdh2tm1Hyn mice
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cardiovascular system
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• exhibited an identical phenotype to the Cdh2-null allele, Cdh2tm1Hyn
• at E9.5, had a malformed heart tube that consisted of rounded and dissociated myocytes surrounding the endocardium
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• severe pericardial swelling at E9
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homeostasis/metabolism
nervous system
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• homozygotes showed a lack of brain development
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mortality/aging
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• mutants die about 2 months after tamoxifen treatment
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cardiovascular system
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• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen
• after tamoxifen treatment intercalated disc structures and intercellular space are absent
• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines
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• after tamoxifen treatment intercalated disc structures are absent
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• modest dilation of the atria after tamoxifen treatment
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• after tamoxifen treatment hearts appear elongated and flacid
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• modest dilation of the ventricles after tamoxifen treatment
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• modest dilation of the ventricles after tamoxifen treatment
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• left ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased
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• about 5 weeks after tamoxifen treatment, mutant heart rate is significantly reduced
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• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death
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• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death
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• tachyarrhythmia is initiated by premature ventricular depolarization
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muscle
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• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen
• after tamoxifen treatment intercalated disc structures and intercellular space are absent
• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines
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• after tamoxifen treatment intercalated disc structures are absent
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• left ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased
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Analysis Tools