All Phenotypes Hdac4<tm1Eno> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hdac4^tm1Eno/Hdac4^tm1Eno	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6)	MGI:3525232
hm2	Hdac4^tm1Eno/Hdac4^tm1Eno	involves: 129	MGI:4418133
cn3	Hdac4^tm1Eno/Hdac4^tm2.1Eno Hdac5^tm1Eno/Hdac5^tm1Eno Tg(Myog-cre)1Eno/0	involves: 129 * 129S/SvEv * 129S2/SvPas	MGI:4418137
cx4	Hdac4^tm1Eno/Hdac4⁺ Hdac5^tm1Eno/Hdac5^tm1Eno Hdac9^tm1Eno/Hdac9⁺	involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:4418139
cx5	Hdac4^tm1Eno/Hdac4^tm1Eno Mef2c^tm1Eno/Mef2c⁺	involves: 129S7/SvEvBrd	MGI:3719020

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:94631 )

• homozygotes are underrepresented by P10 and none survive to weaning

craniofacial

domed cranium ( J:94631 )

• fusion of the occipital sutures prevents longitudinal growth of the skull displacing the brain and producing a domed skull

growth/size/body

decreased body size ( J:94631 )

• by P10 mutants are severely runted

skeleton

domed cranium ( J:94631 )

• fusion of the occipital sutures prevents longitudinal growth of the skull displacing the brain and producing a domed skull

abnormal long bone hypertrophic chondrocyte zone ( J:94631 )

• by P2 hypertrophic chondrocytes are found in the chondrocostal cartilage of mutants but not in wild-type mice

• by P8 a mature ossification center is established and the hypertrophic chondrocytes are replace by trabeculated bone

abnormal costal cartilage morphology ( J:94631 )

• the chondrocostal cartilage which normally does not ossify is almost completely ossified in mutants

abnormal vertebrae morphology ( J:94631 )

• pups have visibly deformed spines as a result of ossification defects

abnormal bone ossification ( J:94631 )

premature endochondral bone ossification ( J:94631 )

• cartilaginous regions in the vertebrae and hyoid bones are completely ossified and premature mineralization was seen in the cartilage of all bones forming through endochondral ossification

• premature ossification can be seen by E18

premature lambdoid suture closure ( J:94631 )

• the occipital sutures are ossified at P8

nervous system

exencephaly ( J:94631 )

• a subset of mutants have exencephaly

Allelic Composition	Hdac4^tm1Eno/Hdac4^tm1Eno
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4^tm1Eno mutation (0 available); any Hdac4 mutation (110 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:127416 )

N	• no change in the abundance of slow fibers

Allelic Composition	Hdac4^tm1Eno/Hdac4^tm2.1Eno Hdac5^tm1Eno/Hdac5^tm1Eno Tg(Myog-cre)1Eno/0
Genetic Background	involves: 129 * 129S/SvEv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4^tm1Eno mutation (0 available); any Hdac4 mutation (110 available)
Hdac4^tm2.1Eno mutation (0 available); any Hdac4 mutation (110 available)
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (56 available)
Tg(Myog-cre)1Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal skeletal muscle fiber type ratio ( J:127416 )

• soleus muscles show an increase in the percentage of slow myofibers

Allelic Composition	Hdac4^tm1Eno/Hdac4⁺ Hdac5^tm1Eno/Hdac5^tm1Eno Hdac9^tm1Eno/Hdac9⁺
Genetic Background	involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4^tm1Eno mutation (0 available); any Hdac4 mutation (110 available)
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (56 available)
Hdac9^tm1Eno mutation (0 available); any Hdac9 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal skeletal muscle fiber type ratio ( J:127416 )

• increase in slow fibers

Allelic Composition	Hdac4^tm1Eno/Hdac4^tm1Eno Mef2c^tm1Eno/Mef2c⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4^tm1Eno mutation (0 available); any Hdac4 mutation (110 available)
Mef2c^tm1Eno mutation (0 available); any Mef2c mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:119152 )

N	• the failure of endochondral ossification that is seen in heterozygous Mef2c mutants is rescued

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