Phenotypes associated with this allele

• Allele Symbol: Tg(Upk2-HRAS*Q61L)12Xrw
• Allele Name: transgene insertion 12, Xue-Ru Wu
• Allele ID: MGI:3522718
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Upk2-HRAS*Q61L)12Xrw/?	involves: FVB/N	MGI:5789929

Genotype
MGI:5789929

tg1

• Allelic Composition: Tg(Upk2-HRAS*Q61L)12Xrw/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:69251 )

• mice die by 5 months of age

neoplasm

increased urinary system tumor incidence ( J:69251 )

• mice develop bladder tumors by 5 months of age

• intraepithelial neovascularization and pseudoglandular structure are prevalent in bladder tumors

renal/urinary system

enlarged kidney ( J:69251 )

enlarged urinary bladder ( J:69251 )

increased urinary system tumor incidence ( J:69251 )

• mice develop bladder tumors by 5 months of age

• intraepithelial neovascularization and pseudoglandular structure are prevalent in bladder tumors

kidney papillary atrophy ( J:69251 )

hydronephrosis ( J:69251 )

• highly dilated renal pelvis resulting from bladder tumors

large ureter ( J:69251 )

abnormal urinary bladder urothelium morphology ( J:69251 )

• urothelium is thickened to 20-30 cell layers

• urothelial hyperplasia is seen at 1 month of age, indicating that hyperplasia precedes papillary tumors

kidney failure ( J:69251 )

growth/size/body

enlarged kidney ( J:69251 )

enlarged urinary bladder ( J:69251 )