Phenotypes associated with this allele

• Allele Symbol: Kcnn3^tm1Jpad
• Allele Name: targeted mutation 1, John P Adelman
• Allele ID: MGI:3522659
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnn3^tm1Jpad/Kcnn3^tm1Jpad	involves: 129S4/SvJae * C57BL/6	MGI:3524861
hm2	Kcnn3^tm1Jpad/Kcnn3^tm1Jpad	Not Specified	MGI:3527279

Genotype
MGI:3524861

hm1

• Allelic Composition: Kcnn3^tm1Jpad/Kcnn3^tm1Jpad
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

pregnancy-related premature death ( J:95064 )

• without doxycycline treatment 7 out of 10 homozygous females had difficult labors with both the mothers and pups failing to survive

• with doxycycline treatment 2 -10 days before labor, females and pups survive

reproductive system

parturition failure ( J:95064 )

♀ • without doxycycline treatment 7 out of 10 homozygous females had difficult labors with both the mothers and pups failing to survive

♀ • with doxycycline treatment 2 -10 days before labor females and pups survive

respiratory system

abnormal pulmonary respiratory rate response ( J:95064 )

• without doxycycline treatment homozygotes are unable to sustain a hypoxia-induced increase in breathing frequency

• after doxycycline treatment for 6 days response to hypoxia is normal

apnea ( J:95064 )

• without doxycycline treatment 3 out of 7 homozygotes had apneic episodes when exposed to hypoxic conditions

Genotype
MGI:3527279

hm2

• Allelic Composition: Kcnn3^tm1Jpad/Kcnn3^tm1Jpad
• Genetic Background: Not Specified

nervous system

nervous system phenotype ( J:94941 )

N • with doxycycline treatment hippocampal morphology and afterhyperpolarization currents are normal