All Phenotypes Kcnn2<tm2Jpad> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kcnn2^tm2Jpad
targeted mutation 2, John P Adelman
MGI:3522587

Summary

2 genotypes

Allelic Composition	Kcnn2^tm2Jpad/Kcnn2^tm2Jpad
Genetic Background	B6.129S4-Kcnn2^tm2Jpad

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnn2^tm2Jpad mutation (1 available); any Kcnn2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• not viable unless treated prenatally with doxycycline

Allelic Composition	Kcnn2^tm2Jpad/Kcnn2⁺
Genetic Background	B6.129S4-Kcnn2^tm2Jpad

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnn2^tm2Jpad mutation (1 available); any Kcnn2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

• four fold increase in the amplitude of apamin sensitive currents in CA1 neurons

• EPSP in CA1 neurons increases136% as opposed to 59% for controls after apamin treatment

• no effect on paired-pulse facilitation

reduced long-term potentiation ( J:105645 )

• LTP induced by three 50Hz tetani was significantly reduced

behavior/neurological

abnormal spatial learning ( J:105645 )

• longer cumulative distance to target in Morris water maze tests

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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