Phenotypes associated with this allele

• Allele Symbol: Kcnn2^tm2Jpad
• Allele Name: targeted mutation 2, John P Adelman
• Allele ID: MGI:3522587
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnn2^tm2Jpad/Kcnn2^tm2Jpad	B6.129S4-Kcnn2^tm2Jpad	MGI:3618093
ht2	Kcnn2^tm2Jpad/Kcnn2^+	B6.129S4-Kcnn2^tm2Jpad	MGI:3618094

Genotype
MGI:3618093

hm1

• Allelic Composition: Kcnn2^tm2Jpad/Kcnn2^tm2Jpad
• Genetic Background: B6.129S4-Kcnn2^tm2Jpad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:105645 )

• not viable unless treated prenatally with doxycycline

Genotype
MGI:3618094

ht2

• Allelic Composition: Kcnn2^tm2Jpad/Kcnn2⁺
• Genetic Background: B6.129S4-Kcnn2^tm2Jpad

nervous system

abnormal CNS synaptic transmission ( J:105645 )

• four fold increase in the amplitude of apamin sensitive currents in CA1 neurons

abnormal excitatory postsynaptic potential ( J:105645 )

• EPSP in CA1 neurons increases136% as opposed to 59% for controls after apamin treatment

• no effect on paired-pulse facilitation

reduced long-term potentiation ( J:105645 )

• LTP induced by three 50Hz tetani was significantly reduced

behavior/neurological

abnormal contextual conditioning behavior ( J:105645 )

abnormal cued conditioning behavior ( J:105645 )

abnormal spatial learning ( J:105645 )

• longer cumulative distance to target in Morris water maze tests