Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd209btm1Anjm mutation
(0 available);
any
Cd209b mutation
(30 available)
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digestive/alimentary system
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• mice exhibit reduced susceptibility to dextran sodium sulfate (DSS)-induced colitis, showing less severe colitis, less shortening of the colon, less inflammation and colon damage, and decreased proinflammatory cytokine levels
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immune system
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• mice exhibit reduced susceptibility to dextran sodium sulfate (DSS)-induced colitis, showing less severe colitis, less shortening of the colon, less inflammation and colon damage, and decreased proinflammatory cytokine levels
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• peritoneal macrophages show reduced LPS-induced lL-1beta production
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• peritoneal macrophages show reduced LPS-induced IL-18 production
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• mice show reduced susceptibility to LPS-induced shock, showing higher survival, reduced clinical signs of shock and reduced proinflammatory levels
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• only 40% of homozygous mutants survive 48 hours after intraperitoneal infection with 103 S. pneumoniae compared to 100% of wild-type and 0% survive after infection with 104 S. pneumoniae compared to 90% in wild-type
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mortality/aging
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• only 40% of homozygous mutants survive 48 hours after intraperitoneal infection with 103 S. pneumoniae compared to 100% of wild-type and 0% survive after infection with 104 S. pneumoniae compared to 90% in wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd209btm1Anjm mutation
(0 available);
any
Cd209b mutation
(30 available)
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immune system
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N |
• mice infected with Schistosoma mansoni show a normal acute and chronic response to infection, showing comparable size and eosinophil content of granulomas surrounding eggs in the liver as in wild-type mice, with no differences in plasma levels of aspartate transaminase and normal downmodulation of inflammatory responses in chronic stages of infection
• mice injected intravenously with schistosome eggs evoke granulomatous inflammation around eggs trapped in the lungs similarly as wild-type mice with no differences in pulmonary egg granulomas
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd209btm1Anjm mutation
(0 available);
any
Cd209b mutation
(30 available)
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immune system
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N |
• mice inoculated with Candida albicans show vaginal fungal burden and polymorphonuclear neutrophil migration to the vagina that are similar to that seen in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd209btm1Anjm mutation
(0 available);
any
Cd209b mutation
(30 available)
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cellular
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• fewer than half as many macrophages phagocytosed S. pneumoniae at 37C compared with controls, with the reduction in phagocytosis being proportional to the reduction in surface binding
• marginal zone macrophages of the spleen failed to phagocytose the polysaccharide dextran
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mortality/aging
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• more rapid mortality after S. pneumoniae infection, with only 20% of homozygotes surviving at 48 hours compared to 90% of wild-type
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immune system
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• peritoneal macrophages were impaired (3-fold reduction) in ability to bind S. pneumoniae at 4C after infection
• marginal zone macrophages in the spleen were impaired in trapping S.pneumoniae in the marginal zone and clearing the bacteria from the circulation
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• fewer than half as many macrophages phagocytosed S. pneumoniae at 37C compared with controls, with the reduction in phagocytosis being proportional to the reduction in surface binding
• marginal zone macrophages of the spleen failed to phagocytose the polysaccharide dextran
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• less than 18% of homozygotes survived infection with S. pneumoniae compared with more than 60% of wild-type and exhibited persistent septicemia after infection compared with controls
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• more rapid mortality after S. pneumoniae infection, with only 20% of homozygotes surviving at 48 hours compared to 90% of wild-type
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hematopoietic system
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• peritoneal macrophages were impaired (3-fold reduction) in ability to bind S. pneumoniae at 4C after infection
• marginal zone macrophages in the spleen were impaired in trapping S.pneumoniae in the marginal zone and clearing the bacteria from the circulation
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• fewer than half as many macrophages phagocytosed S. pneumoniae at 37C compared with controls, with the reduction in phagocytosis being proportional to the reduction in surface binding
• marginal zone macrophages of the spleen failed to phagocytose the polysaccharide dextran
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Analysis Tools