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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Frs2tm2Schl
targeted mutation 2, Joseph Schlessinger
MGI:3521971
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Frs2tm2Schl/Frs2tm2Schl involves: 129S2/SvPas MGI:3717721


Genotype
MGI:3717721
hm1
Allelic
Composition		 Frs2tm2Schl/Frs2tm2Schl
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frs2tm2Schl mutation (0 available); any Frs2 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Variable penetrance of eye defects in Frs2tm1Schl/Frs2tm1Schl and small body size in Frs2tm2Schl/Frs2tm2Schl mice

growth/size/body
decreased fetal size ( J:94724 )
• smaller than wild-type at E14.4

nervous system
nervous system phenotype ( J:102930 )
N
• mice have normal head and brain size

craniofacial
craniofacial phenotype ( J:102930 )
N
• mice have normal head and brain size

vision/eye
vision/eye phenotype ( J:94724 )
N
• evagination of the optic vesicle appears normal at embryonic day 9.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory