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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacng4tm1Frk
targeted mutation 1, Wayne N Frankel
MGI:3521945
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cacng4tm1Frk/Cacng4tm1Frk B6.129-Cacng4tm1Frk MGI:3531473
hm2
 		Cacng4tm1Frk/Cacng4tm1Frk involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3531472
cx3
 		Cacng2stg-wag/Cacng2stg-wag
Cacng4tm1Frk/Cacng4tm1Frk 		involves: B6.MRL-Cacng2stg-wag/J * B6.129-Cacng4tm1Frk/J MGI:3531477
cx4
 		Cacng2stg-3J/Cacng2stg-3J
Cacng4tm1Frk/Cacng4tm1Frk 		involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J MGI:3531478
cx5
 		Cacng2stg-3J/Cacng2stg-3J
Cacng4tm1Frk/Cacng4+ 		involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J MGI:3531479
cx6
 		Cacng2stg-3J/Cacng2+
Cacng4tm1Frk/Cacng4+ 		involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J MGI:3531480
cx7
 		Cacng2stg/Cacng2stg
Cacng4tm1Frk/Cacng4tm1Frk 		involves: B6C3Fe a/a-Cacng2stg/J * B6.129-Cacng4tm1Frk/J MGI:3531476


Genotype
MGI:3531473
hm1
Allelic
Composition		 Cacng4tm1Frk/Cacng4tm1Frk
Genetic
Background		 B6.129-Cacng4tm1Frk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng4tm1Frk mutation (0 available); any Cacng4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:96506 )
• viable and fertile




Genotype
MGI:3531472
hm2
Allelic
Composition		 Cacng4tm1Frk/Cacng4tm1Frk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng4tm1Frk mutation (0 available); any Cacng4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:96506 )
• viable and fertile; no nervous system or behavioral abnormalities were observed including ataxia, subtle movement disorders, seizure activity or in either ERG or ABR recordings




Genotype
MGI:3531477
cx3
Allelic
Composition		 Cacng2stg-wag/Cacng2stg-wag
Cacng4tm1Frk/Cacng4tm1Frk
Genetic
Background		 involves: B6.MRL-Cacng2stg-wag/J * B6.129-Cacng4tm1Frk/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2stg-wag mutation (1 available); any Cacng2 mutation (26 available)
Cacng4tm1Frk mutation (0 available); any Cacng4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:96506 )
• average spike wave discharge duration was 4.8 +/- 4.6 seconds
• average number of spike wave discharges per hour was 37.4 +/- 32.1

growth/size/body
decreased body size ( J:96506 )
• occasional runting was noted; most evident between 2 and 10 weeks of age

nervous system
absence seizures ( J:96506 )
• average spike wave discharge duration was 4.8 +/- 4.6 seconds
• average number of spike wave discharges per hour was 37.4 +/- 32.1




Genotype
MGI:3531478
cx4
Allelic
Composition		 Cacng2stg-3J/Cacng2stg-3J
Cacng4tm1Frk/Cacng4tm1Frk
Genetic
Background		 involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2stg-3J mutation (1 available); any Cacng2 mutation (26 available)
Cacng4tm1Frk mutation (0 available); any Cacng4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:96506 )
• average spike wave discharge duration was 2.3 +/- 1.4 seconds
• average number of spike wave discharges per hour was 24.6 +/- 24.9

growth/size/body
decreased body size ( J:96506 )
• occasional runting was noted; most evident between 2 and 10 weeks of age

nervous system
absence seizures ( J:96506 )
• average spike wave discharge duration was 2.3 +/- 1.4 seconds
• average number of spike wave discharges per hour was 24.6 +/- 24.9




Genotype
MGI:3531479
cx5
Allelic
Composition		 Cacng2stg-3J/Cacng2stg-3J
Cacng4tm1Frk/Cacng4+
Genetic
Background		 involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2stg-3J mutation (1 available); any Cacng2 mutation (26 available)
Cacng4tm1Frk mutation (0 available); any Cacng4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:96506 )
• average spike wave discharge duration was 3.9 +/- 4.5 seconds
• average number of spike wave discharges per hour was 48.6 +/- 29.6

nervous system
absence seizures ( J:96506 )
• average spike wave discharge duration was 3.9 +/- 4.5 seconds
• average number of spike wave discharges per hour was 48.6 +/- 29.6




Genotype
MGI:3531480
cx6
Allelic
Composition		 Cacng2stg-3J/Cacng2+
Cacng4tm1Frk/Cacng4+
Genetic
Background		 involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2stg-3J mutation (1 available); any Cacng2 mutation (26 available)
Cacng4tm1Frk mutation (0 available); any Cacng4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:96506 )
• average spike wave discharge duration was 1.8 +/- 0.5 seconds
• average number of spike wave discharges per hour was 0.3 +/- 0.7

nervous system
absence seizures ( J:96506 )
• average spike wave discharge duration was 1.8 +/- 0.5 seconds
• average number of spike wave discharges per hour was 0.3 +/- 0.7




Genotype
MGI:3531476
cx7
Allelic
Composition		 Cacng2stg/Cacng2stg
Cacng4tm1Frk/Cacng4tm1Frk
Genetic
Background		 involves: B6C3Fe a/a-Cacng2stg/J * B6.129-Cacng4tm1Frk/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2stg mutation (1 available); any Cacng2 mutation (26 available)
Cacng4tm1Frk mutation (0 available); any Cacng4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:96506 )
• most mice that survive birth die before 4 weeks of age
prenatal lethality, incomplete penetrance ( J:96506 )
• incomplete penetrance; very few mutant mice survive to birth




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory