All Phenotypes Erbb2<tm6(Erbb2)Mul> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Erbb2^{tm6(Erbb2)Mul}
targeted mutation 6, William J Muller
MGI:3521859

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb2^{tm6(Erbb2)Mul}/Erbb2^{tm6(Erbb2)Mul}	involves: 129S1/Sv * 129X1/SvJ * BALB/c	MGI:3522497
ht2	Erbb2^{tm6(Erbb2)Mul}/Erbb2^tm1Haus	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c	MGI:3522575

Allelic Composition	Erbb2^{tm6(Erbb2)Mul}/Erbb2^{tm6(Erbb2)Mul}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^{tm6(Erbb2)Mul} mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:94397 )

• homozygotes are normal, healthy, and fertile

Allelic Composition	Erbb2^{tm6(Erbb2)Mul}/Erbb2^tm1Haus
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Haus mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^{tm6(Erbb2)Mul} mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:94397 )

• die shortly after birth struggling unsuccessfully to breathe

respiratory system

respiratory failure ( J:94397 )

nervous system

abnormal phrenic nerve morphology ( J:94397 )

• phrenic nerves are thinned, disorganized, and discontinuous or incomplete and they lack an apparent main nerve trunk from which smaller presynaptic branches originate

defasiculated phrenic nerve ( J:94397 )

abnormal phrenic nerve innervation pattern to diaphragm ( J:94397 )

• diaphragm muscle is very poorly innervated by the phrenic nerve

cellular

defasiculated phrenic nerve ( J:94397 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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