Analysis Tools
normal phenotype
|
• homozygotes are viable, appear healthy, and are fertile
|
|
Allele Symbol Allele Name Allele ID |
Erbb2tm4(Erbb2)Mul targeted mutation 4, William J Muller MGI:3521857 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• homozygotes are viable, appear healthy, and are fertile
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• although the expected numbers of mutants were present at birth, they were either stillborn or started dying immediately after birth
|
|
• cannot breathe despite the ability to open the mouth
• unable to inflate and expand lungs, despite the lungs being vascularized and structurally intact
|
|
• only partial development of the thoracic sympathetic ganglia at E12.5, with defects becoming more severe in a rostral-caudal gradient
|
|
• phrenic nerves are thinned, disorganized, and discontinuous or incomplete and they lack an apparent main nerve trunk from which smaller presynaptic branches originate
|
|
• diaphragm muscle is very poorly innervated by the phrenic nerve
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/30/2024 MGI 6.23 |
|
|
|
||