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Allele Symbol Allele Name Allele ID |
Top2btm2Jcw targeted mutation 2, James C Wang MGI:3521850 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• died of respiratory failure within 30 min after birth, however decreased body size was not observed as in homozygous Top2b mutant mice
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• lack the vigor of wild-type newborns, however show some body movements upon tactile stimulation
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• collapsed lung alveoli in dead pups suggests respiratory failure
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• ill-defined granule cell layer in the hippocampus
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• ill-defined pyramidal cell layer in the hippocampus
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• thinner cortex
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• less developed olfactory bulb
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• retina detached from retinal pigment epithelium at age P14 and P21 owing to absence of OS
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• virtually no OS by age P14
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• m/l-cone outer nuclear layer cells intrude into inner nuclear layer at age P14
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• shorter neural processes on s-cones at age P0
• no neural processes on s-cones at age P7 and P14
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• outer nuclear layer cells intrude into inner nuclear layer at age P14
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• elimination or significant reduction of rhodopsin signal at age P7 and P14
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• increased apoptosis in outer nuclear layer at age P7, P14 and P21
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• by age P14
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• retina detached from RPE at age P14 and P21 owing to absence of outer segment
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• at age P7 and P14
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• absent at age P7, P14 and P21
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• elimination or significant reduction of rhodopsin signal at age P7 and P14
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• retina detached from retinal pigment epithelium at age P14 and P21 owing to absence of OS
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• virtually no OS by age P14
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• m/l-cone outer nuclear layer cells intrude into inner nuclear layer at age P14
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• shorter neural processes on s-cones at age P0
• no neural processes on s-cones at age P7 and P14
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• outer nuclear layer cells intrude into inner nuclear layer at age P14
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• elimination or significant reduction of rhodopsin signal at age P7 and P14
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• increased apoptosis in outer nuclear layer at age P7, P14 and P21
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• by age P14
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• retina detached from RPE at age P14 and P21 owing to absence of outer segment
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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