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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyfip1Gt(XG769)Byg
gene trap XG769, Bay Genomics
MGI:3521835
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:4830278


Genotype
MGI:4830278
hm1
Allelic
Composition		 Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyfip1Gt(XG769)Byg mutation (0 available); any Cyfip1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between somite formation and embryo turning, complete penetrance ( J:163586 )
• embryonic development arrest occurs at around 8.5dpc

embryo
abnormal rostral-caudal body axis extension ( J:163586 )
• the anterior posterior axis of the mutant embryos was not able to further elongate
open neural tube ( J:163586 )
• neural tube closure was not observed in mutant embryos by 9.5dpc
delayed somite formation ( J:163586 )
• mutant embryos had only 6-12 somties at 9.5dpc, which is the somite number for the normal embryos at 8.5dpc
impaired somite development ( J:163586 )
• although the somite structures were visible, they appeared disorganized

nervous system
open neural tube ( J:163586 )
• neural tube closure was not observed in mutant embryos by 9.5dpc




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory