Phenotypes associated with this allele

• Allele Symbol: Met^tm3Gvw
• Allele Name: targeted mutation 3, George Vande Woude
• Allele ID: MGI:3521829
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Met^tm3Gvw/Met^tm3Gvw	involves: 129 * C57BL/6J	MGI:3521984

Genotype
MGI:3521984

hm1

• Allelic Composition: Met^tm3Gvw/Met^tm3Gvw
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:94722 )

• shorter lifespan (10.6-12.5 months) compared to controls (20.5 months)

neoplasm

increased tumor incidence ( J:94722 )

• 83.8% tumor incidence compared to 44.4% in controls

increased hemangiosarcoma incidence ( J:94722 )

• high frequency of hemangiosarcomas that were histologically unique compared to hemangiosarcomas found in wild-type mice

cellular

chromosome breakage ( J:94722 )

• trisomy and tetrasomy of chromosome 6 and duplication of the mutant Met allele were observed in tumors