Analysis Tools
normal phenotype
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• growth is normal and no histological abnormalities were detected through 15 months of age
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Allele Symbol Allele Name Allele ID |
Pkd1tm1.1Djmp targeted mutation 1.1, Dorien JM Peters MGI:3521724 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• growth is normal and no histological abnormalities were detected through 15 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• adult mice treated with tamoxifen for 3 to 5 months exhibit a 5- to 20-fold increase in proliferation index for precystic tubular epithelial cells compared to wild-type mice
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• mice exhibit 1-5 cysts after 1 months of treatment with tamoxifen beginning at 3 months of age and about 10 cysts after 3 months that are bilateral and in the cortex and medulla
• mice develop massive cysts 1 month after exposure to tamoxifen by breast feeding beginning at 4 days of age that arise from distal parts of the nephron and are uromodulin-positive
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• adult mice treated with tamoxifen beginning at 3 months of age develop severe polycystic kidney disease that is more severe in males despite similar recombination efficiencies in both genders
• after 1 month, mice treated with tamoxifen by breast feeding beginning at 4 days of age exhibit more severe polycystic kidney disease then their mothers sacrificed 1 to 5 months after initiation of treatment
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• at 5 months, mice treated with tamoxifen beginning at 3 months of age exhibit a kidney to body weight ratio of 2% to 9.5% compared to 1.3% to 1.8% in wild-type mice
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• after 1 months of treatment with tamoxifen beginning at 3 months of age
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• at 5 months, mice treated with tamoxifen beginning at 3 months of age exhibit pale kidneys
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• by 4 to 11 months of age mice treated with tamoxifen beginning at 3 months of age develop liver cysts
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• adult mice treated with tamoxifen for 3 to 5 months exhibit a 5- to 20-fold increase in proliferation index for precystic tubular epithelial cells compared to wild-type mice
|
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• mice exhibit 1-5 cysts after 1 months of treatment with tamoxifen beginning at 3 months of age and about 10 cysts after 3 months that are bilateral and in the cortex and medulla
• mice develop massive cysts 1 month after exposure to tamoxifen by breast feeding beginning at 4 days of age that arise from distal parts of the nephron and are uromodulin-positive
|
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• adult mice treated with tamoxifen beginning at 3 months of age develop severe polycystic kidney disease that is more severe in males despite similar recombination efficiencies in both genders
• after 1 month, mice treated with tamoxifen by breast feeding beginning at 4 days of age exhibit more severe polycystic kidney disease then their mothers sacrificed 1 to 5 months after initiation of treatment
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• by 4 to 11 months of age mice treated with tamoxifen beginning at 3 months of age develop liver cysts
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• at 5 months, mice treated with tamoxifen beginning at 3 months of age exhibit a kidney to body weight ratio of 2% to 9.5% compared to 1.3% to 1.8% in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with tamoxifen exhibit a slightly milder phenotype than in Pkd1tm1.1Djmp/Pkd1tm1.2Djmp Tg(Cdh16-cre/ERT2)F427Djmp mice
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• mice treated with tamoxifen exhibit a slightly milder phenotype than in Pkd1tm1.1Djmp/Pkd1tm1.2Djmp Tg(Cdh16-cre/ERT2)F427Djmp mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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