Phenotypes associated with this allele

• Allele Symbol: Tg(Ttr-Foxo1)307Dac
• Allele Name: transgene insertion 307, Domenico Accili
• Allele ID: MGI:3521643
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ttr-Foxo1)307Dac/0	involves: C57BL/6J	MGI:3521739
tg2	Tg(Ttr-Foxo1)307Dac/0	involves: FVB * C57BL/6	MGI:3653872

Genotype
MGI:3521739

tg1

• Allelic Composition: Tg(Ttr-Foxo1)307Dac/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:94423 )

• higher plasma cholesterol levels in heparinized transgenic mice (136 mg/dl) compared to wild-type (109 mg/dl)

increased circulating HDL cholesterol level ( J:94423 )

increased circulating triglyceride level ( J:94423 )

• approximately twofold increase in plasma triglyceride levels and elevated plasma VLDL-triglyceride levels

• triglyceride levels were elevated in response to a fat tolerance test and remained high even after 4 hours compared to wild-type

Genotype
MGI:3653872

tg2

• Allelic Composition: Tg(Ttr-Foxo1)307Dac/0
• Genetic Background: involves: FVB * C57BL/6

homeostasis/metabolism

hyperglycemia ( J:79560 )

• hyperglycemia at 2 months of age in the fed state

increased circulating insulin level ( J:79560 )

• mild hyperinsulinemia at 2 months of age

impaired glucose tolerance ( J:79560 )

• deterioration of glucose tolerance between 2 and 6 months of age

increased insulin sensitivity ( J:79560 )

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:79560 )

• cross section area 3X greater than in controls