|
Allele Symbol Allele Name Allele ID |
Tg(KRT14-HPV16E7)2350Plam transgene insertion 2350, Paul F Lambert MGI:3514323 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no mice survive past weaning
|
|
• small bilateral cataracts are seen at birth
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• an increase in apoptotic cells is seen in hair follicles
|
|
• only about 2% of mice survive past the first 2 weeks of life
|
|
• growth is severely stunted through the first 2 months of life; however, surviving mice eventually reach normal body size and weight
|
|
• small bilateral cataracts are seen at birth
|
|
• the thickness of the nucleated layer is increased in squamous epithelia in the upper digestive tract
|
|
• squamous epithelia in the forestomach is highly invaginated
|
|
• an increase in apoptotic cells is seen in hair follicles
|
|
• mice appear scruffy with less dense fur
|
|
• the fur often appears greasy and matted
|
|
• the fur often appears greasy and matted
|
|
• about a 5-fold increase in apoptosis primarily in the stratum granulosum and these apoptotic cells occur in patches
• squamous epithelia in the skin is highly invaginated
|
|
• clearly seen in adult ears
• a disorganized pattern of proliferating cells is seen in the skin with many proliferating cells that are not in contact with the basement membrane present
• hyperproliferation of epithelial cells results in lateral and vertical expansion of the affected epithelium
|
|
• first seen at P3 in most mice
|
|
• the skin on the ears and/or snout is thickened in neonatal and adult mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||
Analysis Tools