Phenotypes associated with this allele

• Allele Symbol: Hoxb6^tm1Cka
• Allele Name: targeted mutation 1, Claudia Kappen
• Allele ID: MGI:3514269
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb6^tm1Cka/Hoxb6^tm1Cka	involves: 129P2/OlaHsd * C57BL/6	MGI:3785158

Genotype
MGI:3785158

hm1

• Allelic Composition: Hoxb6^tm1Cka/Hoxb6^tm1Cka
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased rib number ( J:133561 )

• mice lack the first pair of ribs

vertebral transformation ( J:133561 )

• mice exhibit an anterior transformation with vertebra C6 through T3 exhibiting the characteristics of C5 through T2

hematopoietic system

abnormal definitive hematopoiesis ( J:133561 )

• cultured bone marrow cells form more erythroid colonies consisting of erythroid burst-forming unites (BFU-E) and erythroid colony forming units (CFU-E) than wild-type bone marrow cells

• however, differentiation of other lineages is normal

abnormal erythropoiesis ( J:133561 )

• fetal liver cells generate more erythroid burst-forming units than cells from wild-type mice

immune system

immune system phenotype ( J:133561 )

N • mice exhibit normal immune function