Phenotypes associated with this allele

• Allele Symbol: Apbb1^tm1Quhu
• Allele Name: targeted mutation 1, Qubai Hu
• Allele ID: MGI:3514266
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apbb1^tm1Quhu/Apbb1^tm1Quhu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3522085
ht2	Apbb1^tm1Quhu/Apbb1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3522086

Genotype
MGI:3522085

hm1

• Allelic Composition: Apbb1^tm1Quhu/Apbb1^tm1Quhu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal passive avoidance behavior ( J:94887 )

• at 14 months, impaired acquisition of passive avoidance learning (shorter step through latencies at days 2 and 3 after training)

abnormal spatial learning ( J:94887 )

• 14 month old mutants displayed impaired hippocampal-dependent spatial learning and memory tasks in the hidden platform (spatial) version of the Morris water-maze and in probe tests

• at 14 months, very poor performance in reversal spatial learning, indicating that mutants are deficient in extinction of old spatial references

• displayed normal learning and memory in the visible platform (nonspatial) version of the water-maze and normal locomotor activity in an open-field test

Genotype
MGI:3522086

ht2

• Allelic Composition: Apbb1^tm1Quhu/Apbb1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

behavior/neurological

abnormal passive avoidance behavior ( J:94887 )

• at 14 months, impaired acquisition of passive avoidance learning (shorter step through latencies at days 2 and 3 after training than wild-type but longer than in homozygotes)

abnormal spatial learning ( J:94887 )

• 14 month old mutants showed an intermediate performance (worse than wild-type but better than homozygotes) in the hidden platform version of the Morris water-maze, but displayed normal learning and memory in the visible platform (nonspatial) version of the water-maze, in reversal learning, and normal locomotor activity in an open-field test