About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igk-J+
wild type
MGI:3513980
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Igk-Jtm2Mwg/Igktm1Dhu involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:3717904
cx2
 		Igkctm1(IGKC)Mnz/Igkc+
Igk-Jtm1(CD4*)Mss/Igk-J+ 		involves: 129S4/SvJae MGI:3829707
cx3
 		Igh-Jtm1Dim/Igh-J+
Igk-Jtm1Dim/Igk-J+ 		involves: 129S4/SvJae * C57BL/6 MGI:3640188
cx4
 		Igk-Jtm1Mwg/Igktm1Dhu involves: 129S7/SvEvBrd * C57BL/6 MGI:3717905
cx5
 		Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Igk-Jtm1Mwg/Igk-J+ 		involves: C57BL/6 * NZB MGI:3513981


Genotype
MGI:3717904
cx1
Allelic
Composition		 Igk-Jtm2Mwg/Igktm1Dhu
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk-Jtm2Mwg mutation (7 available); any Igk-J mutation (9 available)
Igktm1Dhu mutation (2 available); any Igk mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:76116 )
N
• IgM density at the pre-B and immature B cell stages is indistinguishable from wild-type mice




Genotype
MGI:3829707
cx2
Allelic
Composition		 Igkctm1(IGKC)Mnz/Igkc+
Igk-Jtm1(CD4*)Mss/Igk-J+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1(IGKC)Mnz mutation (2 available); any Igkc mutation (9 available)
Igk-Jtm1(CD4*)Mss mutation (0 available); any Igk-J mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin light chain V-J recombination ( J:143876 )
• mice were bred to carry the two mutant alleles in trans
• a 2:1 skew in favor of expression of the Igk-Ctm1(IGKC)Mnz allele among immature and mature B cells suggests the CD4 knock-in allele causes a recombination defect

hematopoietic system
abnormal immunoglobulin light chain V-J recombination ( J:143876 )
• mice were bred to carry the two mutant alleles in trans
• a 2:1 skew in favor of expression of the Igk-Ctm1(IGKC)Mnz allele among immature and mature B cells suggests the CD4 knock-in allele causes a recombination defect




Genotype
MGI:3640188
cx3
Allelic
Composition		 Igh-Jtm1Dim/Igh-J+
Igk-Jtm1Dim/Igk-J+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dim mutation (1 available); any Igh-J mutation (12 available)
Igk-Jtm1Dim mutation (1 available); any Igk-J mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:107241 )
• the bone marrow contains an increase in the proportion of immature B cells and decrease in the proportion of mature B cells probably as the result of removal of cells expressing high-affinity anti-glucose-6-phosphate specificities during maturation
increased IgG level ( J:107241 )
• detectable levels of anti-glucose-6-phosphate IgG unlike in wild-type mice
increased IgM level ( J:107241 )
• 3- to 10-fold increase in the anti-glucose-6-phosphate IgM titer

hematopoietic system
abnormal B cell differentiation ( J:107241 )
• the bone marrow contains an increase in the proportion of immature B cells and decrease in the proportion of mature B cells probably as the result of removal of cells expressing high-affinity anti-glucose-6-phosphate specificities during maturation
increased IgG level ( J:107241 )
• detectable levels of anti-glucose-6-phosphate IgG unlike in wild-type mice
increased IgM level ( J:107241 )
• 3- to 10-fold increase in the anti-glucose-6-phosphate IgM titer




Genotype
MGI:3717905
cx4
Allelic
Composition		 Igk-Jtm1Mwg/Igktm1Dhu
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk-Jtm1Mwg mutation (1 available); any Igk-J mutation (9 available)
Igktm1Dhu mutation (2 available); any Igk mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:76116 )
N
• IgM density at the pre-B and immature B cell stages is indistinguishable from wild-type mice




Genotype
MGI:3513981
cx5
Allelic
Composition		 Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Igk-Jtm1Mwg/Igk-J+
Genetic
Background		 involves: C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Dkit mutation (1 available); any Blnk mutation (77 available)
Igh-Jtm1(3H9-VDJ)Mwg mutation (4 available); any Igh-J mutation (12 available)
Igk-Jtm1Mwg mutation (1 available); any Igk-J mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immature B cell morphology ( J:94297 )
• decreased number of B cells in bone marrow and spleen
• receptor editing of dsDNA binding BCR replacing kappa chain with lamda was hampered resulting in suppression of lambda + B cells to 5% (compared to 22% in cells with wild-type Blnk)

immune system
abnormal immature B cell morphology ( J:94297 )
• decreased number of B cells in bone marrow and spleen
• receptor editing of dsDNA binding BCR replacing kappa chain with lamda was hampered resulting in suppression of lambda + B cells to 5% (compared to 22% in cells with wild-type Blnk)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory