About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igk-Jtm1Mwg
targeted mutation 1, Martin Weigert
MGI:3513200
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Igk-Jtm1Mwg/Igktm1Dhu involves: 129S7/SvEvBrd * C57BL/6 MGI:3717905
cx2
 		Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Igk-Jtm1Mwg/Igk-J+ 		involves: C57BL/6 * NZB MGI:3513981


Genotype
MGI:3717905
cx1
Allelic
Composition		 Igk-Jtm1Mwg/Igktm1Dhu
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk-Jtm1Mwg mutation (1 available); any Igk-J mutation (11 available)
Igktm1Dhu mutation (1 available); any Igk mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:76116 )
N
• IgM density at the pre-B and immature B cell stages is indistinguishable from wild-type mice




Genotype
MGI:3513981
cx2
Allelic
Composition		 Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Igk-Jtm1Mwg/Igk-J+
Genetic
Background		 involves: C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Dkit mutation (1 available); any Blnk mutation (76 available)
Igh-Jtm1(3H9-VDJ)Mwg mutation (4 available); any Igh-J mutation (13 available)
Igk-Jtm1Mwg mutation (1 available); any Igk-J mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immature B cell morphology ( J:94297 )
• decreased number of B cells in bone marrow and spleen
• receptor editing of dsDNA binding BCR replacing kappa chain with lamda was hampered resulting in suppression of lambda + B cells to 5% (compared to 22% in cells with wild-type Blnk)

immune system
abnormal immature B cell morphology ( J:94297 )
• decreased number of B cells in bone marrow and spleen
• receptor editing of dsDNA binding BCR replacing kappa chain with lamda was hampered resulting in suppression of lambda + B cells to 5% (compared to 22% in cells with wild-type Blnk)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory