Phenotypes associated with this allele

• Allele Symbol: Klk1^tm1Pmtn
• Allele Name: targeted mutation 1, Pierre Meneton
• Allele ID: MGI:3513115
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klk1^tm1Pmtn/Klk1^tm1Pmtn	involves: 129/Sv * C57BL/6	MGI:3612961
hm2	Klk1^tm1Pmtn/Klk1^tm1Pmtn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3513509

Genotype
MGI:3612961

hm1

• Allelic Composition: Klk1^tm1Pmtn/Klk1^tm1Pmtn
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal uterine artery morphology ( J:103928 )

♀ • 7 days after pregnancy, a medial hypertrophy of uterine arteries persists while the structural lumen diameter regresses to normal

increased heart weight ( J:103928 )

• heart weight is increased by day 18 to 19 of pregnancy

decreased vasodilation ( J:103928 )

• significantly smaller flow-induced uterine arterial dilation

• during pregnancy, flow-induced uterine arterial dilation remains smaller

muscle

decreased vasodilation ( J:103928 )

• significantly smaller flow-induced uterine arterial dilation

• during pregnancy, flow-induced uterine arterial dilation remains smaller

growth/size/body

increased heart weight ( J:103928 )

• heart weight is increased by day 18 to 19 of pregnancy

Genotype
MGI:3513509

hm2

• Allelic Composition: Klk1^tm1Pmtn/Klk1^tm1Pmtn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

cardiovascular system

abnormal heart morphology ( J:67868 )

thin interventricular septum ( J:67868 )

• the septum is thinner

decreased heart left ventricle weight ( J:67868 )

• left ventricular mass is reduced

decreased heart left ventricle posterior wall thickness ( J:67868 )

• left ventricular posterior wall is thinner

abnormal cardiovascular system physiology ( J:67868 )

• no bradykinin can be detected in the heart

decreased cardiac output ( J:67868 )

• decreased stroke volume without any significant change in heart rate results in decreased cardiac output

decreased cardiac stroke volume ( J:67868 )

• stroke volume is decreased

decreased ventricle muscle contractility ( J:67868 )

• left ventricular fractional shortening is decreased and in isolated work-performing hearts systolic pressure and external power are reduced at high afterload and preload, respectively

decreased vasodilation ( J:67868 )

• flow-dependent but not acetylcholine-induced vasodilation is impaired

muscle

decreased ventricle muscle contractility ( J:67868 )

• left ventricular fractional shortening is decreased and in isolated work-performing hearts systolic pressure and external power are reduced at high afterload and preload, respectively

decreased vasodilation ( J:67868 )

• flow-dependent but not acetylcholine-induced vasodilation is impaired