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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox10tm2(rtTA)Weg
targeted mutation 2, Michael Wegner
MGI:3513104
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox10tm2(rtTA)Weg/Sox10tm2(rtTA)Weg involves: 129P2/OlaHsd MGI:3513117
ht2
 		Sox10tm2(rtTA)Weg/Sox10+ involves: 129P2/OlaHsd MGI:3513122
cx3
 		Hprt1tm1(tetO-Runx1,-EGFP)Enk/Hprt1+
Sox10tm2(rtTA)Weg/Sox10+ 		involves: 129P2/OlaHsd MGI:4840038


Genotype
MGI:3513117
hm1
Allelic
Composition		 Sox10tm2(rtTA)Weg/Sox10tm2(rtTA)Weg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm2(rtTA)Weg mutation (0 available); any Sox10 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:94207 )
• died during late embryonic development or perinatally
prenatal lethality, incomplete penetrance ( J:94207 )
• died during late embryonic development or perinatally




Genotype
MGI:3513122
ht2
Allelic
Composition		 Sox10tm2(rtTA)Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm2(rtTA)Weg mutation (0 available); any Sox10 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belly spot ( J:94207 )
• with increasing numbers of backcrosses, nearly all heterozygotes developed a white belly spot

digestive/alimentary system
megacolon ( J:94207 )
• in early backcrosses, a few heterozygotes developed megacolon

integument
belly spot ( J:94207 )
• with increasing numbers of backcrosses, nearly all heterozygotes developed a white belly spot




Genotype
MGI:4840038
cx3
Allelic
Composition		 Hprt1tm1(tetO-Runx1,-EGFP)Enk/Hprt1+
Sox10tm2(rtTA)Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(tetO-Runx1,-EGFP)Enk mutation (0 available); any Hprt1 mutation (1279 available)
Sox10tm2(rtTA)Weg mutation (0 available); any Sox10 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:165939 )
• doxycycline-treated mice die 2 to 3 days after birth

nervous system
small dorsal root ganglion ( J:165939 )
• in doxycycline-treated mice

digestive/alimentary system
megacolon ( J:165939 )
• in doxycycline-treated mice

behavior/neurological
hyperresponsive to tactile stimuli ( J:165939 )
• in doxycycline-treated mice after a chronic constriction injury

growth/size/body
decreased birth body size ( J:165939 )
• in doxycycline-treated mice

pigmentation
abnormal skin pigmentation ( J:165939 )
• at birth in doxycycline-treated mice

integument
abnormal skin pigmentation ( J:165939 )
• at birth in doxycycline-treated mice




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory