Phenotypes associated with this allele

• Allele Symbol: Map2^repro4
• Allele Name: reproductive mutant 4, JAX Reproductive Mutagenesis Program
• Allele ID: MGI:3512900
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2^repro4/Map2^repro4	B6;C3Fe-Map^repro4/J	MGI:3709014
hm2	Map2^repro4/Map2^repro4	C3.B6-Map2^repro4	MGI:5544322

Genotype
MGI:3709014

hm1

• Allelic Composition: Map2^repro4/Map2^repro4
• Genetic Background: B6;C3Fe-Map^repro4/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal germ cell morphology ( J:92463 )

• some germ cells appear apoptotic

azoospermia ( J:92463 )

♂ • no sperm recovered

decreased testis weight ( J:92463 )

♂ • very low testis weight

arrest of male meiosis ( J:92463 )

♂ • arrest of germ cells during late pachytene stage of meiotic prophase

male infertility ( J:92463 )

♂

endocrine/exocrine glands

decreased testis weight ( J:92463 )

♂ • very low testis weight

cellular

abnormal germ cell morphology ( J:92463 )

• some germ cells appear apoptotic

azoospermia ( J:92463 )

♂ • no sperm recovered

Genotype
MGI:5544322

hm2

• Allelic Composition: Map2^repro4/Map2^repro4
• Genetic Background: C3.B6-Map2^repro4

reproductive system

reproductive system phenotype ( J:205107 )

N • males produce plugs normally in females

decreased testis weight ( J:205107 )

• weight 1/3 that of controls

abnormal spermatogenesis ( J:205107 )

abnormal spermatid morphology ( J:205107 )

• very few round spermatids at 24 days of age

abnormal spermatocyte morphology ( J:205107 )

• increased apoptotic spermatocytes by 17 days of age

arrest of male meiosis ( J:205107 )

• at mid pachytene stage of prophase of meiosis I

• ome spermatocytes do advance

• spermatogonial proliferation is normal however

arrest of spermiogenesis ( J:205107 )

• very few epididymal sperm

endocrine/exocrine glands

decreased testis weight ( J:205107 )

• weight 1/3 that of controls

cellular

abnormal spermatid morphology ( J:205107 )

• very few round spermatids at 24 days of age

abnormal spermatocyte morphology ( J:205107 )

• increased apoptotic spermatocytes by 17 days of age