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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pias4tm1Rug
targeted mutation 1, Rudolf Grosschedl
MGI:3512663
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pias4tm1Rug/Pias4tm1Rug involves: 129S2/SvPas * C57BL/6 MGI:3512758


Genotype
MGI:3512758
hm1
Allelic
Composition		 Pias4tm1Rug/Pias4tm1Rug
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pias4tm1Rug mutation (0 available); any Pias4 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:94291 )
• fewer than expected homozygous mutants are found after E18.5

hematopoietic system
abnormal myelopoiesis ( J:94291 )
• a 25% increase in the number of Mac1+GR1+ myeloid cells is seen, however the number of T and B cells is normal

immune system
abnormal myelopoiesis ( J:94291 )
• a 25% increase in the number of Mac1+GR1+ myeloid cells is seen, however the number of T and B cells is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory